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In this study, the mechanism by which the interleukin (IL)\u201023\/IL\u201017 axis regulates RNV in oxygen\u2010induced retinopathy (OIR) model mice and in cell experiments in vitro was characterized. In the retinas of OIR mice, IL\u201023\/IL\u201017 axis activation was increased and regulated RNV formation, and this effect was accompanied by increased macrophage recruitment and nucleotide\u2010binding domain leucine\u2010rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome activation. Moreover, inhibiting the IL\u201023\/IL\u201017 axis reduced the number of macrophage and the expression and activation of NLRP3 inflammasome. On the other hand, recombinant (r) IL\u201023p19 and rIL\u201017A promoted the expression and activation of NLRP3 inflammasome, and the proliferation and migration of macrophages. Furthermore, macrophage elimination decreased the activation of IL\u201023\/IL\u201017 axis and the expression and activation of NLRP3 inflammasome. In summary, our experiments showed that the IL\u201023\/IL\u201017 axis promoted the formation of RNV by activating the NLRP3 inflammasome in retinal macrophages of an OIR mouse model.<\/jats:p>","DOI":"10.1111\/imm.13402","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T05:27:00Z","timestamp":1629091620000},"page":"803-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The IL\u201023\/IL\u201017 axis promotes the formation of retinal neovascularization by activating the NLRP3 inflammasome in macrophages in an experimental retinopathy mouse model"],"prefix":"10.1111","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5803-9253","authenticated-orcid":false,"given":"Ailing","family":"Sui","sequence":"first","affiliation":[{"name":"The Department of Ophthalmology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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