{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:41:47Z","timestamp":1787067707530,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST\u2010109\u20102628\u2010B\u2010006\u2010019"],"award-info":[{"award-number":["MOST\u2010109\u20102628\u2010B\u2010006\u2010019"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST\u2010110\u20102628\u2010B\u2010006\u2010023"],"award-info":[{"award-number":["MOST\u2010110\u20102628\u2010B\u2010006\u2010023"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    IL\u201020 is a proinflammatory cytokine of the IL\u201010 family and involved in several diseases. However, the regulatory role of IL\u201020 in obesity is not well understood. We explored the function of IL\u201020 in the pathogenesis of obesity\u2010induced insulin resistance by ELISA, Western blotting and flow cytometry. The therapeutic potential of IL\u201020\u00a0monoclonal antibody 7E for ameliorating diet\u2010induced obesity was analysed in murine models. Higher serum IL\u201020\u00a0levels were detected in obese patients. It was upregulated in leptin\u2010deficient (\n                    <jats:italic>ob<\/jats:italic>\n                    \/\n                    <jats:italic>ob<\/jats:italic>\n                    ), leptin\u2010resistant (\n                    <jats:italic>db<\/jats:italic>\n                    \/\n                    <jats:italic>db<\/jats:italic>\n                    ) and high\u2010fat diet (HFD)\u2010induced murine obesity models.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , IL\u201020 regulated the adipocyte differentiation and the polarization of bone marrow\u2010derived macrophages into proinflammatory M1 type. It also caused inflammation and macrophage retention in adipose tissues by upregulating TNF\u2010\u03b1, monocyte chemotactic protein 1 (MCP\u20101), netrin 1 and unc5b (netrin receptor) expression in macrophages and netrin 1, leptin and MCP\u20101 in adipocytes. IL\u201020 promoted insulin resistance by inhibiting glucose uptake in mature adipocytes through the SOCS\u20103 pathway. In HFD\u2010induced obesity in mice, 7E treatment reduced body weight and improved glucose tolerance and insulin sensitivity; it also reduced local inflammation and the number of M1\u2010like macrophages in adipose tissues. We have identified a critical role of IL\u201020 in obesity\u2010induced inflammation and insulin resistance, and we conclude that IL\u201020\u00a0may be a novel target for treating obesity and insulin resistance in patients with metabolic disorders.\n                  <\/jats:p>","DOI":"10.1111\/imm.13403","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T14:13:02Z","timestamp":1629209582000},"page":"817-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["IL\u201020 is involved in obesity by modulation of adipogenesis and macrophage dysregulation"],"prefix":"10.1111","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2738-2638","authenticated-orcid":false,"given":"Yu\u2010Hsiang","family":"Hsu","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine College of Medicine National Cheng Kung University Tainan Taiwan"},{"name":"Research Center of 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