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Long non\u2010coding RNAs have been reported to act as important regulators of many pathological processes. However, very little is known regarding the role of lncRNAs during B\u2010cell development and the regulation of their expression. In this study, we explored the expression and role of lncRNA Gme00492 in B\u2010cell development. We observed that lnc00492 was highly expressed in B\u2010cell development and primarily expressed in the nucleus. Lnc00492\u2010deficient mice had fewer marginal zone B cells in the spleen, likely due to a developmental block. Importantly, lnc00492 interacts with CTBP1 and targets it for ubiquitination and degradation during B\u2010cell development, whereas the transcriptional corepressor factor CTBP1 plays a critical role in Notch2\u00a0signalling. Thus, we identified a novel regulatory axis between lnc00492 and CTBP1 in B cells, suggesting that lnc00492 is essential for marginal zone B\u2010cell development.<\/jats:p>","DOI":"10.1111\/imm.13408","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T08:31:17Z","timestamp":1629966677000},"page":"88-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["LncRNA00492 is required for marginal zone B\u2010cell development"],"prefix":"10.1111","volume":"165","author":[{"given":"Faming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Medical School of Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongya","family":"Cui","sequence":"additional","affiliation":[{"name":"Biomedical Research Center of South China Fujian Normal University  Fuzhou China"},{"name":"The Key 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