{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:11:54Z","timestamp":1693415514913},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurodegenerative diseases place a devastating burden on affected individuals and their families, and new treatments are desperately needed for these common immune\u2010mediated inflammatory conditions. While large aggregates of abnormal proteins in the brain cause significant damage, it is becoming clear that smaller soluble protein aggregates can also contribute to disease, by both direct and indirect mechanisms. These soluble protein oligomers can be found in patients' serum. Here, we describe recent research that identifies effects of model oligomer molecules on peripheral blood T cells, therefore providing an additional mechanism by which neurodegeneration may be worsened through amplification of peripheral adaptive immune responses.<\/jats:p>","DOI":"10.1111\/imm.13414","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T13:27:48Z","timestamp":1631712468000},"page":"209-210","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Do peripheral protein oligomers in neurodegenerative diseases shape T cell responses beyond the brain?"],"prefix":"10.1111","volume":"164","author":[{"given":"Annabelle","family":"Ferguson","sequence":"first","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow  Glasgow UK  <!--Query ID=\"q3\" Text=\"AUTHOR: Please check that authors and their affiliations are correct.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Milling","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation University of Glasgow  Glasgow UK  <!--Query ID=\"q3\" Text=\"AUTHOR: Please check that authors and their affiliations are correct.\"-->"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008862"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2003.5.1\/hhippius"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13279"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03225.x"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.283"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12233"},{"key":"e_1_2_2_9_1","first-page":"1","article-title":"Towards PET imaging of the dynamic phenotypes of microglia","author":"Beaino W","year":"2021","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0023-4"},{"key":"e_1_2_2_11_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/imm.13377","article-title":"Distinct responses of human peripheral blood cells to different misfolded protein oligomers","volume":"164","author":"Leal\u2010Lasarte M","year":"2021","journal-title":"Immunology"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.13414","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:11:29Z","timestamp":1693296689000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.13414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,15]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/imm.13414"],"URL":"https:\/\/doi.org\/10.1111\/imm.13414","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,15]]},"assertion":[{"value":"2021-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}