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Various armours including oxidative burst, NETs and proteases function against pathogens, but also dispose neutrophils to spawn pro\u2010inflammatory responses. Neutrophils undergo death through different pathways upon ageing, infection, executing the intruder's elimination. These include non\u2010lytic apoptosis and other lytic deaths including NETosis, necroptosis and pyroptosis with distinct disintegration of the cellular membrane. This causes release and presence of different intracellular cytotoxic, and tissue\u2010damaging content as cell remnants in the extracellular environment. The apoptotic cells and apoptotic bodies get cleared with non\u2010inflammatory outcomes, while lytic deaths associated remnants including histones and cell\u2010free DNA cause pro\u2010inflammatory responses. Indeed, the enhanced frequencies of neutrophil\u2010associated proteases, cell\u2010free DNA and autoantibodies in diverse pathologies including sepsis, asthma, lupus and rheumatoid arthritis, imply disturbed neutrophil resolution programmes in inflammatory and autoimmune diseases. Thus, the clearance mechanisms of neutrophils and associated remnants are vital for therapeutics. Though studies focused on clearance mechanisms of senescent or apoptotic neutrophils so far generated a good understanding of the same, clearance of neutrophils undergoing distinct lytic deaths, including NETs, are being the subjects of intense investigations. Here, in this review, we are providing the current updates in the clearance mechanisms of apoptotic neutrophils and focusing on not so well\u2010defined recognition, uptake and degradation of neutrophils undergoing lytic death and associated remnants that may provide new therapeutic approaches in inflammation and autoimmunity.<\/jats:p>","DOI":"10.1111\/imm.13423","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:59:41Z","timestamp":1635296381000},"page":"22-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":157,"title":["Neutrophil and remnant clearance in immunity and inflammation"],"prefix":"10.1111","volume":"165","author":[{"given":"Apurwa","family":"Singhal","sequence":"first","affiliation":[{"name":"Pharmacology Division CSIR\u2010Central Drug Research Institute  Lucknow Uttar Pradesh 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