{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:14:46Z","timestamp":1793592886945,"version":"4.5.0"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/01299"],"award-info":[{"award-number":["PI18\/01299"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/01187"],"award-info":[{"award-number":["PI21\/01187"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n Mutua Madrile\u00f1a","doi-asserted-by":"publisher","award":["AP176182020"],"award-info":[{"award-number":["AP176182020"]}],"id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>COVID\u201019 disease is the manifestation of syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection, which is causing a worldwide pandemic. This disease can lead to multiple and different symptoms, being lymphopenia associated with severity one of the most persistent. Natural killer cells (NK cells) are part of the innate immune system, being fighting against virus\u2010infected cells one of their key roles. In this study, we determined the phenotype of NK cells after COVID\u201019 and the main characteristic of SARS\u2010CoV\u20102\u2010specific\u2010like NK population in the blood of convalescent donors. CD57+ NKG2C+ phenotype in SARS\u2010CoV\u20102 convalescent donors indicates the presence of \u2018memory\u2019\/activated NK cells as it has been shown for cytomegalovirus infections. Although the existence of this population is donor dependent, its expression may be crucial for the specific response against SARS\u2010CoV\u20102, so that, it gives us a tool for selecting the best donors to produce off\u2010the\u2010shelf living drug for cell therapy to treat COVID\u201019 patients under the RELEASE clinical trial (NCT04578210).<\/jats:p>","DOI":"10.1111\/imm.13432","type":"journal-article","created":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T17:01:53Z","timestamp":1636909313000},"page":"234-249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Identifying SARS\u2010CoV\u20102 \u2018memory\u2019 NK cells from COVID\u201019 convalescent donors for adoptive cell therapy"],"prefix":"10.1111","volume":"165","author":[{"given":"Lara","family":"Herrera","sequence":"first","affiliation":[{"name":"Research Unit Basque Center for Blood Transfusion and Human Tissues  Osakidetza, Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Martin\u2010Inaraja","sequence":"additional","affiliation":[{"name":"Research Unit Basque Center for Blood Transfusion and Human Tissues  Osakidetza, Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Santos","sequence":"additional","affiliation":[{"name":"Research Unit Basque Center for Blood Transfusion and Human Tissues  Osakidetza, Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ingl\u00e9s\u2010Ferr\u00e1ndiz","sequence":"additional","affiliation":[{"name":"Research Unit Basque Center for Blood Transfusion and Human Tissues  Osakidetza, Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Azkarate","sequence":"additional","affiliation":[{"name":"Research Unit Basque Center for Blood Transfusion and Human Tissues  Osakidetza, Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Perez\u2010Vaquero","sequence":"additional","affiliation":[{"name":"Research Unit Basque Center for Blood Transfusion and Human Tissues  Osakidetza, Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Vesga","sequence":"additional","affiliation":[{"name":"Research Unit Basque Center for Blood Transfusion and Human Tissues  Osakidetza, Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Vicario","sequence":"additional","affiliation":[{"name":"Histocompatibility Centro de Transfusi\u00f3n de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernat","family":"Soria","sequence":"additional","affiliation":[{"name":"Instituto de Bioingenier\u00eda Universidad Miguel Hern\u00e1ndez de Elche  Alicante Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital General y Universitario de Alicante (ISABIAL)  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Solano","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico Universitario de Valencia\/Instituto de Investigaci\u00f3n Sanitaria INCLIVA  Valencia Spain"},{"name":"School of Medicine University of Valencia  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"De Paz","sequence":"additional","affiliation":[{"name":"Hematology Department University Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Marcos","sequence":"additional","affiliation":[{"name":"Hematology Department University Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ferreras","sequence":"additional","affiliation":[{"name":"Hospital La Paz Institute for Health Research IdiPAZ University Hospital La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Perez\u2010Martinez","sequence":"additional","affiliation":[{"name":"Hospital La Paz Institute for Health Research IdiPAZ University Hospital La Paz  Madrid Spain"},{"name":"Pediatric Hemato\u2010Oncology Department University Hospital La Paz  Madrid Spain"},{"name":"Faculty of Medicine Universidad Aut\u00f3noma de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8738-2077","authenticated-orcid":false,"given":"Cristina","family":"Eguizabal","sequence":"additional","affiliation":[{"name":"Research Unit Basque Center for Blood Transfusion and Human Tissues  Osakidetza, Galdakao Spain"},{"name":"Cell Therapy, Stem Cells and Tissues Group Biocruces Bizkaia Health Research Institute  Barakaldo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"WHO.Coronavirus disease (COVID\u201019) outbreak situation reports(available athttps:\/\/www.who.int\/emergencies\/diseases\/novel\u2010coronavirus\u20102019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.01.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.04.086"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173644"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001282"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015301"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2020.0228"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.620730"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00892"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MR0820-685R"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11899-012-0136-z"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006999"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02381"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16354"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.12.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.580237"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201712085"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0402-2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22302"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501783"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00060"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-04-425397"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00909"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01363"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.01.022"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.3.1455"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198687"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.9"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003035"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2010.162"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100762"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002268"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2021.108727"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3682"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445320"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1110900108"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00169-17"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12785"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646819"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI140965"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14573"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00504"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735416679515"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910607"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00558-3"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01512"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00362-20"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324176"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102561"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2020.109777"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21508"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abd6832"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-10-459545"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00686"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2011.10.017"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.03027.x"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00384"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404499"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.680480"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040304"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000196"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.09.003"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0082-6"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.029"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00923-3"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.358"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.14047"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2020.08.004"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101332"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12698"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa047"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30076"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines8020224"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072657"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1465324921002905"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.13432","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:14:07Z","timestamp":1693196047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.13432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,2]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/imm.13432"],"URL":"https:\/\/doi.org\/10.1111\/imm.13432","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,2]]},"assertion":[{"value":"2021-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}