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The function of MR in immune cells such as macrophages and T cells has been increasingly appreciated. The aim of this study was to investigate the function of Treg MR in the process of inflammatory bowel disease (IBD). We treated Treg MR\u2010deficient (<jats:italic>MR<\/jats:italic><jats:sup><jats:italic>flox\/flox<\/jats:italic><\/jats:sup><jats:italic>Foxp3<\/jats:italic><jats:sup><jats:italic>YFP\u2010Cre<\/jats:italic><\/jats:sup>, KO) mice and control (<jats:italic>Foxp3<\/jats:italic><jats:sup><jats:italic>YFP\u2010Cre<\/jats:italic><\/jats:sup>, WT) mice with dextran sodium sulphate (DSS) to induce colitis and found that the severity of DSS\u2010induced colitis was markedly alleviated in Treg MR\u2010deficient mice, accompanied by reduced production of inflammatory cytokines, and relieved infiltration of monocytes, neutrophils and interferon \u03b3<jats:sup>+<\/jats:sup> T cells in colon lamina propria. Faecal microbiota of mice with colitis was analysed by 16S rRNA gene sequencing and the composition of gut microbiota was vastly changed in Treg MR\u2010deficient mice. Furthermore, depletion of gut microbiota by antibiotics abolished the protective effects of Treg MR deficiency and resulted in similar severity of DSS\u2010induced colitis in WT and KO mice. Faecal microbiota transplantation from KO mice attenuated DSS\u2010induced colitis characterized by alleviated inflammatory infiltration compared to that from WT mice. Hence, our study demonstrates that Treg MR deficiency protects against DSS\u2010induced colitis by attenuation of colonic inflammatory infiltration. Gut microbiota is both sufficient and necessary for Treg MR deficiency to exert the beneficial effects.<\/jats:p>","DOI":"10.1111\/imm.13522","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T17:23:22Z","timestamp":1656177802000},"page":"94-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mineralocorticoid receptor deficiency in Treg cells ameliorates DSS\u2010induced colitis in a gut microbiota\u2010dependent manner"],"prefix":"10.1111","volume":"167","author":[{"given":"Ting","family":"Liu","sequence":"first","affiliation":[{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital, College of Stomatology Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology  Shanghai 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