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Regulatory cytokines such as TGF\u2010\u03b2 can restrain inflammatory reactions, dampen allergic Th2 responses, and control eosinophil activation. The murine helminth parasite <jats:italic>Heligmosomoides polygyrus<\/jats:italic> releases a TGF\u2010\u03b2 mimic (<jats:italic>Hp\u2010<\/jats:italic>TGM) that replicates the biological and functional properties of TGF\u2010\u03b2 despite bearing no structural similarity to the mammalian protein. Here, we investigated if <jats:italic>Hp<\/jats:italic>\u2010TGM could alleviate allergic airway inflammation in mice exposed to <jats:italic>Alternaria alternata<\/jats:italic> allergen, house dust mite (HDM) extract or alum\u2010adjuvanted ovalbumin protein (OVA). Intranasal administration of <jats:italic>Hp\u2010<\/jats:italic>TGM during <jats:italic>Alternaria<\/jats:italic> exposure sharply reduced airway and lung tissue eosinophilia along with bronchoalveolar lavage fluid IL\u20105 and lung IL\u201033 cytokine levels at 24\u2009h. The protective effect of <jats:italic>Hp\u2010<\/jats:italic>TGM on airway eosinophilia was also obtained in the longer T\u2010cell mediated models of HDM or OVA sensitisation with significant inhibition of eotaxin\u20101, IL\u20104 and IL\u201013 responses depending on the model and time\u2010point. <jats:italic>Hp\u2010<\/jats:italic>TGM was also protective when administered parenterally either when given at the time of allergic sensitisation or during airway allergen challenge. This project has taken the first steps in identifying the role of <jats:italic>Hp<\/jats:italic>\u2010TGM in allergic asthma and highlighted its ability to control lung inflammation and allergic pathology. Future research will investigate the mode of action of <jats:italic>Hp<\/jats:italic>\u2010TGM against airway allergic eosinophilia, and further explore its potential to be developed as a biotherapeutic in allergic asthma.<\/jats:p>","DOI":"10.1111\/imm.13528","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T08:56:34Z","timestamp":1656320194000},"page":"197-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Suppression of airway allergic eosinophilia by <scp><i>Hp<\/i>\u2010TGM<\/scp>, a helminth mimic of <scp>TGF<\/scp>\u2010\u03b2"],"prefix":"10.1111","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9127-4693","authenticated-orcid":false,"given":"Caroline","family":"Chauch\u00e9","sequence":"first","affiliation":[{"name":"Wellcome Centre for Integrative Parasitology Institute of Infection, Immunity and Inflammation, University of Glasgow  Glasgow 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