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We previously reported that stroke induces an ablation of multiple sub\u2010populations of B cells and reduces levels of immunoglobulin M (IgM) antibody, which coincides with the development of spontaneous bacterial pneumonia. The loss of IgM after stroke could be an important determinant of infection susceptibility and highlights this pathway as a target for intervention. We treated mice with a replacement dose of IgM\u2010enriched intravenous immunoglobulin (IgM\u2010IVIg) prior to and 24\u2009h after middle cerebral artery occlusion (MCAO) and allowed them to recover for 2\u2010 or 5\u2010day post\u2010surgery. Treatment with IgM\u2010IVIg enhanced bacterial clearance from the lung after MCAO and improved lung pathology but did not impact brain infarct volume. IgM\u2010IVIg treatment induced immunomodulatory effects systemically, including rescue of splenic plasma B cell numbers and endogenous mouse IgM and IgA circulating immunoglobulin concentrations that were reduced by MCAO. Treatment attenuated MCAO\u2010induced elevation of selected pro\u2010inflammatory cytokines in the lung. IgM\u2010IVIg treatment did not increase the number of lung mononuclear phagocytes or directly modulate macrophage phagocytic capacity but enhanced phagocytosis of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    bioparticles in vitro. Low\u2010dose IgM\u2010IVIg contributes to increased clearance of spontaneous lung bacteria after MCAO likely via increasing availability of antibody in the lung to enhance opsonophagocytic activity. Immunomodulatory effects of IgM\u2010IVIg treatment may also contribute to reduced levels of damage in the lung after MCAO. IgM\u2010IVIg shows promise as an antibacterial and immunomodulatory agent to use in the treatment of post\u2010stroke infection.\n                  <\/jats:p>","DOI":"10.1111\/imm.13553","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T16:47:27Z","timestamp":1658854047000},"page":"558-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Treatment with\n                    <scp>IgM<\/scp>\n                    \u2010enriched intravenous immunoglobulins enhances clearance of stroke\u2010associated bacterial lung infection"],"prefix":"10.1111","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1396-6643","authenticated-orcid":false,"given":"Laura","family":"McCulloch","sequence":"first","affiliation":[{"name":"Centre for Inflammation Research, Institute for Regeneration and Repair University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4114-783X","authenticated-orcid":false,"given":"Alison J.","family":"Harris","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5144-3333","authenticated-orcid":false,"given":"Alexandra","family":"Malbon","sequence":"additional","affiliation":[{"name":"Easter Bush Pathology, The Royal (Dick) School of Veterinary Studies and The Roslin Institute University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-5626","authenticated-orcid":false,"given":"Michael J. 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Northern Care Alliance NHS Group University of Manchester  Manchester UK"},{"name":"Lydia Becker Institute of Immunology and Inflammation, Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health University of Manchester, Manchester Academic Health Science Centre  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-4456","authenticated-orcid":false,"given":"Stuart M.","family":"Allan","sequence":"additional","affiliation":[{"name":"Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"},{"name":"Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Group University of Manchester  Manchester 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