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One of the first pieces of evidence characterizing the SARS\u2010CoV\u20102 infection has been its breadth of clinical presentation, ranging from asymptomatic to severe\/deadly disease, and the indication of the key role played by the immune response in influencing disease severity. This review is aimed at summarizing what the SARS\u2010CoV\u20102 infection taught us about the immune response, highlighting its features of a double\u2010edged sword mediating both protective and pathogenic processes. We will discuss the protective role of soluble and cellular innate immunity and the detrimental power of a hyper\u2010inflammation\u2010shaped immune response, resulting in tissue injury and immunothrombotic events. 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