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The effect and mechanism of exhausted CD8<jats:sup>+<\/jats:sup> T cells have become the focus of anti\u2010tumour immunity research. Recently, a large number of studies have confirmed that long\u2010term antigen exposure can induce exhaustion. Cytokines previously have identified their effects (such as IL\u20102 and IL\u201010) may play a dual role in the exhaustion process of CD8<jats:sup>+<\/jats:sup> T cells, suggesting a new mechanism of inducing exhaustion. This review just focuses our current understanding of the biology of exhausted CD8<jats:sup>+<\/jats:sup> T cells, including differentiation pathways, cellular characteristics and signalling pathways involved in inducing exhaustion, and summarizes how these can be applied to tumour immunotherapy.<\/jats:p>","DOI":"10.1111\/imm.13588","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T16:24:14Z","timestamp":1664814254000},"page":"30-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["<scp>CD8<\/scp><sup>+<\/sup> T cell exhaustion in anti\u2010tumour immunity: The new insights for cancer immunotherapy"],"prefix":"10.1111","volume":"168","author":[{"given":"Yijin","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Sciences Beijing Normal University  Beijing 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