{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:30:33Z","timestamp":1792161033683,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010767","name":"Innovative Medicines Initiative","doi-asserted-by":"publisher","award":["777357"],"award-info":[{"award-number":["777357"]}],"id":[{"id":"10.13039\/501100010767","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010089","name":"JGW Patterson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012295","name":"NIHR Newcastle Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["22072"],"award-info":[{"award-number":["22072"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Age\u2010associated B cells (ABCs) are an immune cell subset linked to autoimmunity, infection and ageing, and whose pathophysiological importance was recently highlighted using single cell synovial tissue profiling. To elucidate their pathophysiological relevance, peripheral blood (PB) ABCs from early rheumatoid arthritis (eRA) patients na\u00efve to disease\u2010modifying anti\u2010rheumatic drugs (DMARDs) were compared with their synovial fluid (SF) counterparts, and to PB ABCs from psoriatic arthritis patients and healthy controls. PB and SF B\u2010cell subsets were phenotyped by multi\u2010parameter flow cytometry, sorted and subjected to gene expression profiling (NanoString nCounter\u00ae Immunology V2 Panel) and functional characterization (stimulated cytokine measurements by immunoassay). PB ABCs of eRA patients, which are transcriptionally distinct from those of control cohorts, express chemokine receptors and adhesion molecules, such as CXCR3, that favour homing to inflammatory sites over lymphoid tissue. These cells are an activated, class\u2010switched B\u2010cell subset expressing high levels of HLA\u2010DR, co\u2010stimulatory molecules and T\u2010bet. Their secretion profile includes IL\u201012p70 and IL\u201023 but low levels of IL\u201010. High surface expression of FcRL family members, including FcRL3, furthermore suggests a role for these cells in autoimmunity. Finally, and unlike in the periphery where they are rare, ABCs are the predominant B\u2010cell subsets in SF. These observations indicate the predilection of ABCs for inflammatory tissue in RA, where their propensity for antigen presentation and pro\u2010inflammatory phenotype may support autoimmune pathology. Their potential as a therapeutic target therefore warrants further study.<\/jats:p>","DOI":"10.1111\/imm.13598","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T07:13:10Z","timestamp":1666681990000},"page":"640-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Characterization of age\u2010associated B cells in early drug\u2010na\u00efve rheumatoid arthritis patients"],"prefix":"10.1111","volume":"168","author":[{"given":"Gemma","family":"Vidal\u2010Pedrola","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-4811","authenticated-orcid":false,"given":"Najib","family":"Naamane","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Institute for Inflammation and Ageing University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9909-8209","authenticated-orcid":false,"given":"Arthur G.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"},{"name":"Musculoskeletal Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9553-6160","authenticated-orcid":false,"given":"Andrew L.","family":"Mellor","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6103-7056","authenticated-orcid":false,"given":"John D.","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"},{"name":"Musculoskeletal Unit Newcastle upon Tyne Hospitals NHS Foundation Trust  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Scheel\u2010Toellner","sequence":"additional","affiliation":[{"name":"Institute for Inflammation and Ageing University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-623X","authenticated-orcid":false,"given":"Amy E.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.03.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-330530"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-331462"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13068"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1078\/0171-2985-00198"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.05.010"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.5A0416-182R"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2000.01379.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12792"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0378-1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204116"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.03.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-243071"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03750-7"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501209"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8365-8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI91250"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.09.007"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes279"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3252"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-10-r106"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.154.9.4341"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aab4176"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12736"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.07218"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2017.07.006"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201911-2151OC"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.08.015"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.41641"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40393"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.12.910"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.099"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102651"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201243068"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901982"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-353102"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10622"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25508"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.03.020"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.01.002"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2022.104533"},{"issue":"3","key":"e_1_2_10_44_1","first-page":"551","article-title":"Structure of and signal transduction through interleukin\u20104 and interleukin\u201013 receptors (review)","volume":"1","author":"Murata T","year":"1998","journal-title":"Int J Mol Med"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1733"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.13598","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T19:45:43Z","timestamp":1692560743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.13598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,10]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/imm.13598"],"URL":"https:\/\/doi.org\/10.1111\/imm.13598","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,10]]},"assertion":[{"value":"2022-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}