{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:43:04Z","timestamp":1793400184019,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE023838"],"award-info":[{"award-number":["R01 DE023838"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DE030646"],"award-info":[{"award-number":["R01 DE030646"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 AI142273"],"award-info":[{"award-number":["R03 AI142273"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 DE028033"],"award-info":[{"award-number":["R03 DE028033"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56 DE023838"],"award-info":[{"award-number":["R56 DE023838"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 DE031058"],"award-info":[{"award-number":["R21 DE031058"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sj\u04e7gren's syndrome (SS) is an autoimmune inflammatory disease characterized by chronic inflammation and dysfunction of exocrine glands and causes dry mouth, dry eyes and various systemic health problems. The objective of this study is to define the in vivo actions of the endogenous NLRP3 inflammasome, a key initiator and mediator of various immune and inflammatory conditions, in newly established SS disease. MCC950, a highly specific small\u2010molecule inhibitor of NLRP3 inflammasome formation and activation, was intraperitoneally administered to the female non\u2010obese diabetic (NOD) mice aged 11\u2009weeks, which have newly established SS\u2010like hyposalivation and pathologies. The injection was conducted three times weekly for three consecutive weeks and mice were analysed for characteristic SS pathologies at the end of the treatments. MCC950 treatment resulted in a marked reduction in salivary secretion and an exacerbation of leukocyte infiltration of submandibular glands. The disease\u2010worsening effect of MCC950 treatment was accompanied by increased T and B cell numbers, enhanced T helper 1 response and reduced aquaporin 5 expression in submandibular glands. Hence, ablation of endogenous NLRP3 inflammasome activity by MCC950 with established autoimmune exocrinopathy exacerbates salivary gland dysfunction and inflammation, indicating a disease\u2010alleviating and inflammation\u2010dampening action of the endogenous NLRP3 inflammasome activity during established SS disease in the non\u2010obese diabetic mouse model.<\/jats:p>","DOI":"10.1111\/imm.13605","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:09:07Z","timestamp":1668046147000},"page":"697-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inhibition of\n                    <scp>NLRP3<\/scp>\n                    inflammasome activity by\n                    <scp>MCC950<\/scp>\n                    leads to exacerbation of Sj\u04e7gren's syndrome pathologies in non\u2010obese diabetic mice"],"prefix":"10.1111","volume":"168","author":[{"given":"Jing","family":"Zhou","sequence":"first","affiliation":[{"name":"The Forsyth Institute  Cambridge Massachusetts USA"},{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoko","family":"Onodera","sequence":"additional","affiliation":[{"name":"The Forsyth Institute  Cambridge Massachusetts USA"},{"name":"Department of Biochemistry Tokyo Dental College  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5818-0564","authenticated-orcid":false,"given":"Qing","family":"Yu","sequence":"additional","affiliation":[{"name":"The Forsyth Institute  Cambridge Massachusetts USA"},{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-46"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.118"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8008-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu417"},{"issue":"2","key":"e_1_2_10_8_1","first-page":"179","article-title":"One year in review 2017: primary Sjogren's syndrome","volume":"35","author":"Ferro F","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206297"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01181.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.S1-009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-8011-8"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2010.09.009"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00958.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0300-9475.2004.01508.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2010.164"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2016.141"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.04.010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.05.014"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.04.003"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.02.009"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000473"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00036"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.09.002"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.149"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1513509112"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3806"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309575"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002767"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26775-w"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12115"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.790741"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew013"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23073"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2013.754427"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2898"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700487"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2008.70"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00072.2012"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3202"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI94524"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2017.12.021"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.06.020"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205496"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.5865"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.3.1230"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39105"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-017-0013-4"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.29.20071"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1601992113"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171419"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02538"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1413-8"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.01.015"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/243723"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309348234"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.6.3205"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304498110"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.12.8153"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13605","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.13605","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.13605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T19:45:10Z","timestamp":1692560710000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.13605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,18]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/imm.13605"],"URL":"https:\/\/doi.org\/10.1111\/imm.13605","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,18]]},"assertion":[{"value":"2022-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}