{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:47Z","timestamp":1787014367554,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T00:00:00Z","timestamp":1685923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1I1A1A01054533"],"award-info":[{"award-number":["2020R1I1A1A01054533"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1I1A2055591"],"award-info":[{"award-number":["2020R1I1A2055591"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2B5B02001578"],"award-info":[{"award-number":["2021R1A2B5B02001578"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A6A1A03033084"],"award-info":[{"award-number":["2019R1A6A1A03033084"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Autosomal recessive (AR) and dominant (AD) deficiencies of TLR3 and TRIF are believed to be crucial genetic causes of herpes simplex encephalitis (HSE), which is a fatal disease causing focal or global cerebral dysfunction following infection with herpes simplex virus type 1 (HSV\u20101). However, few studies have been conducted on the immunopathological networks of HSE in the context of TLR3 and TRIF defects at the cellular and molecular levels. In this work, we deciphered the crosstalk between type I IFN (IFN\u2010I)\u2010producing epithelial layer and IL\u201015\u2010producing dendritic cells (DC) to activate NK cells for the protective role of TLR3\/TRIF pathway in HSE progression after vaginal HSV\u20101 infection. TLR3\u2010 and TRIF\u2010ablated mice showed enhanced susceptibility to HSE progression, along with high HSV\u20101 burden in vaginal tract, lymphoid tissues and CNS. The increased HSV\u20101 burden in TLR3\u2010 and TRIF\u2010ablated mice did not correlate with increased infiltration of Ly\u20106C\n                    <jats:sup>+<\/jats:sup>\n                    monocytes, but it was closely associated with impaired NK cell activation in vaginal tract. Furthermore, using delicate ex vivo experiments and bone marrow transplantation, TRIF deficiency in tissue\u2010resident cells, such as epithelial cells in vaginal tract, was found to cause impaired NK cell activation by means of low IFN\u2010I production, whereas IFN\u2010I receptor in DC was required for NK cell activation via IL\u201015 production in response to IFN\u2010I produced from epithelial layer. These results provide new information about IFN\u2010I\u2010 and IL\u201015\u2010mediated crosstalk between epithelial cells and DC at the primary infection site, which suppresses HSE progression in a TLR3\u2010 and TRIF\u2010dependent manner.\n                  <\/jats:p>","DOI":"10.1111\/imm.13664","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T21:15:51Z","timestamp":1686172551000},"page":"83-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["TLR3\/TRIF pathway confers protection against herpes simplex encephalitis through NK cell activation mediated by a loop of type I IFN and IL\u201015 from epithelial and dendritic cells"],"prefix":"10.1111","volume":"170","author":[{"given":"Erdenebileg","family":"Uyangaa","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and Bio\u2010Safety Research Institute Jeonbuk National University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Bio\u2010Safety Research Institute Jeonbuk National University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Ok","family":"Park","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Bio\u2010Safety Research Institute Jeonbuk National University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Won","family":"Byeon","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Bio\u2010Safety Research Institute Jeonbuk National University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Won","family":"Cho","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Bio\u2010Safety Research Institute Jeonbuk National University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koanhoi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine Pusan National University  Yangsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Kug","family":"Eo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Bio\u2010Safety Research Institute Jeonbuk National University  Iksan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-020-02127-5"},{"key":"e_1_2_12_3_1","first-page":"33","article-title":"Immunomodulatory strategies in herpes simplex virus encephalitis","volume":"12","author":"Piret J","year":"2020","journal-title":"Clin Microbiol 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