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Three NiV strains NiV\u2010Malaysia (NiV<jats:sub>M<\/jats:sub>), NiV Bangladesh (NiV<jats:sub>B<\/jats:sub>), and NiV India (NiV<jats:sub>I<\/jats:sub> reported in 2019) have been circulating in South\u2010Asian nations. Sporadic outbreak observed in South\u2010East Asian countries but human to human transmission raises the concern about its pandemic potential. The presence of the viral genome in reservoir bats has further confirmed that NiV has spread to the African and Australian continents. NiV research activities have gained momentum to achieve specific preparedness goals to meet any future emergency\u2014as a result, several potential vaccine candidates have been developed and tested in a variety of animal models. Some of these candidate vaccines have entered further clinical trials. Research activities related to the discovery of therapeutic monoclonal antibodies (mAbs) have resulted in the identification of a handful of candidates capable of neutralizing the virion. However, progress in discovering potential antiviral drugs has been limited. Thus, considering NiV's pandemic potential, it is crucial to fast\u2010track ongoing projects related to vaccine clinical trials, anti\u2010NiV therapeutics. Here, we discuss the current progress in NiV\u2010vaccine research and therapeutic options, including mAbs and antiviral medications.<\/jats:p>","DOI":"10.1111\/imm.13695","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T09:41:52Z","timestamp":1694770912000},"page":"155-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Advancements in <scp>Nipah<\/scp> virus treatment: <scp>Analysis<\/scp> of current progress in vaccines, antivirals, and therapeutics"],"prefix":"10.1111","volume":"171","author":[{"given":"Gayatree","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Biological Science Indian Institute of Science Education and Research Bhopal  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Prajapat","sequence":"additional","affiliation":[{"name":"Department of Biological Science Indian Institute of Science Education and Research Bhopal  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4762-4553","authenticated-orcid":false,"given":"Debasis","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Biological Science Indian Institute of Science Education and Research Bhopal  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"Henipavirus nipahense[cited 2023 Aug 8]. 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