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Mechanism promoting the main respiratory viruses entry and virus\u2010evocated innate and adaptive immune responses have now been elucidated, and an oxidative stress central role in these pathogenic processes has been recognized. Presence of reactive oxygen species in macrophages and other cells allows them to eliminate virus, but its excess alters the balance between innate and adaptive immune responses and proteases\/anti\u2010proteases and leads to uncontrolled inflammation, tissue damage, and hypercoagulability. Different upper and lower airway cell types also play a role in viral entry and infection. Carbocysteine is a muco\u2010active drug with anti\u2010oxidant and anti\u2010inflammatory properties used for the management of several chronic respiratory diseases. Although the use of anti\u2010oxidants has been proposed as an effective strategy in COPD exacerbations management, the molecular mechanisms that explain carbocysteine efficacy have not yet been fully clarified. The present review describes the most relevant features of the common respiratory virus pathophysiology with a focus on epithelial cells and oxidative stress role and reports data supporting a putative role of carbocysteine in viral respiratory infections.<\/jats:p>","DOI":"10.1111\/imm.13762","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:09:10Z","timestamp":1707955750000},"page":"329-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of airway epithelium in viral respiratory infections: Can carbocysteine prevent or mitigate them?"],"prefix":"10.1111","volume":"172","author":[{"given":"Elisabetta","family":"Pace","sequence":"first","affiliation":[{"name":"Istituto di Farmacologia Traslazionale\u2010Consiglio Nazionale delle Ricerche  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Di 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