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MDSCs are characterized by their strong T\u2010cell immunosuppressive capacity. The effects that MDSCs may have on B cells, especially within the tumour microenvironment, are less well understood. Here, we report that either monocytic MDSCs or polymorphonuclear MDSCs can promote increases in interleukin (IL)\u201010\u2010expressing CD19<jats:sup>hi<\/jats:sup>Fc\u03b3RIIb<jats:sup>hi<\/jats:sup> regulatory B cells in vitro and in vivo. Splenic transitional\u20101, \u20102, and \u20103 cells and marginal zone B cells, but not follicular B cells, differentiate into IL\u201010\u2010expressing CD19<jats:sup>hi<\/jats:sup>Fc\u03b3RIIb<jats:sup>hi<\/jats:sup> regulatory B cells. The adoptive transfer of CD19<jats:sup>hi<\/jats:sup>Fc\u03b3RIIb<jats:sup>hi<\/jats:sup> regulatory B cells via tail vein injection can promote subcutaneous 3LL tumour growth in mice. The expression of programmed death\u2010ligand 1 on MDSCs was found to be strongly associated with CD19<jats:sup>hi<\/jats:sup>Fc\u03b3RIIb<jats:sup>hi<\/jats:sup> regulatory B cell population expansion. Furthermore, the frequency of circulating CD19<jats:sup>+<\/jats:sup>Fc\u03b3RII<jats:sup>hi<\/jats:sup> regulatory B cells was significantly increased in advanced\u2010stage lung cancer patients. Our results unveil a critical role of MDSCs in regulatory B\u2010cell differentiation and population expansion in lung cancer patients.<\/jats:p>","DOI":"10.1111\/imm.13763","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T06:59:15Z","timestamp":1707461955000},"page":"127-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Myeloid\u2010derived suppressor cells from tumour\u2010bearing mice induce the population expansion of <scp>CD19<sup>hi<\/sup>Fc\u03b3RIIb<sup>hi<\/sup><\/scp> regulatory <scp>B<\/scp> cells via <scp>PD\u2010L1<\/scp>"],"prefix":"10.1111","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6872-7378","authenticated-orcid":false,"given":"Wenyan","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, Medical College Yangzhou University  Yangzhou 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