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In the current research, the effect of methyl\u2010supplemented nutrition on the development of SLE was studied in the pristane\u2010induced mouse model of the disease. The results clearly demonstrated decreased anti\u2010dsDNA antibody and proteinuria levels, modulation of cytokines and protected renal structures in the group of treated mice. An additional increase in the DNA methylation of mouse B lymphocytes was also observed. The beneficial effect of the diet is due to the methyl\u2010containing micronutrients with possible anti\u2010inflammatory and immunomodulating effects on cell proliferation and gene expression. Since these components are responsible for maintaining the physiological methylation level of DNA, the results point to the central role of methylation processes in environmentally triggered lupus. As nutrition represents one of the major epigenetic factors, these micronutrients may be considered novel agents with significant therapeutic outcomes.<\/jats:p>","DOI":"10.1111\/imm.13774","type":"journal-article","created":{"date-parts":[[2024,3,2]],"date-time":"2024-03-02T13:30:10Z","timestamp":1709386210000},"page":"269-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Methyl\u2010supplemented nutrition delays the development of autoimmune disease in pristane\u2010induced murine lupus"],"prefix":"10.1111","volume":"172","author":[{"given":"Silviya","family":"Bradyanova","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Immunology, Department of Immunology \u201cThe Stephan Angeloff\u201d Institute of Microbiology, Bulgarian Academy of Sciences  Sofia 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