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Monotherapy with programmed death 1 (PD\u20101)\/programmed death ligand 1 (PD\u2010L1) inhibitors is ineffective for treating MSS CRC, making immunotherapy for MSS CRC a bottleneck. Recent studies have found that the multi\u2010pathway regimens combined with PD\u20101\/PD\u2010L1 inhibitors can enhance the efficacy of anti\u2010PD\u20101\/PD\u2010L1 in MSS CRC by increasing the number of CD8+ T cells, upregulating PD\u2010L1 expression and improving the tumour microenvironment. This paper reviews the research progress of PD\u20101\/PD\u2010L1 inhibitors in combination with cytotoxic T\u2010lymphocyte\u2013associated antigen 4 (CTLA\u20104) inhibitors, oncolytic virus, intestinal flora, antiangiogenic agents, chemotherapy, radiotherapy and epigenetic drugs for the treatment of pMMR\u2010MSI\u2010L\/MSS CRC.<\/jats:p>","DOI":"10.1111\/imm.13785","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T07:44:35Z","timestamp":1711093475000},"page":"209-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["A new strategy for immunotherapy of\n                    <scp>microsatellite\u2010stable (MSS)<\/scp>\n                    \u2010type advanced colorectal cancer: Multi\u2010pathway combination therapy with\n                    <scp>PD<\/scp>\n                    \u20101\/\n                    <scp>PD\u2010L1<\/scp>\n                    inhibitors"],"prefix":"10.1111","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8582-8152","authenticated-orcid":false,"given":"Lingli","family":"Cai","sequence":"first","affiliation":[{"name":"Clinical Medical College Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Medical College Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Institute of General Surgery, Clinical Medical College, Yangzhou University, Northern Jiangsu People's Hospital  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"e_1_2_12_2_1","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and 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