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Three ovarian endometriosis patients were collected, and single\u2010cell RNA sequencing (scRNA\u2010seq) progressed and delineated the cellular landscape of endometriosis containing five cell clusters. The endometrial cells (EMCs) were the major component, of which the mesenchymal cells were preponderant and characterized with increased inflammation and oestrogen synthesis in endometriosis. The proportion of T cells, mainly CD8<jats:sup>+<\/jats:sup> T cells rather than CD4<jats:sup>+<\/jats:sup>, was reduced in endometriotic lesions, and the cytokines and cytotoxicity of ectopic T cells were depressed. CD8<jats:sup>+<\/jats:sup> T cells depressed the proliferation of ESCs through inhibiting CDK1\/CCNB1 pathway to arrest the cell cycle and triggered inflammation through activating STAT1 pathway. Correspondingly, the coculture with ESCs resulted in the dysfunction of CD8<jats:sup>+<\/jats:sup> T cells through upregulating STAT1\/PDCD1 pathway and glycolysis\u2010promoted metabolism reprogramming. The endometriotic lesions were larger in nude mouse models with T\u2010cell deficiency than the normal mouse models. The inhibition of T cells via CD90.2 or CD8A antibody increased the endometriotic lesions in mouse models, and the supplement of T cells to nude mouse models diminished the lesion sizes. In conclusion, this study revealed the global cellular variation of endometriosis among which the cellular count and physiology of EMCs and T cells were significantly changed. The depressed cytotoxicity and aberrant metabolism of CD8<jats:sup>+<\/jats:sup> T cells were induced by ESCs with the activation of STAT1\/PDCD1 pathway resulting in immune survival to promote endometriosis.<\/jats:p>","DOI":"10.1111\/imm.13786","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T05:30:59Z","timestamp":1711603859000},"page":"469-485","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The dysfunction of <scp>CD8<\/scp><sup>+<\/sup> T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis"],"prefix":"10.1111","volume":"172","author":[{"given":"Zhi\u2010Xiong","family":"Huang","sequence":"first","affiliation":[{"name":"Clinical Medical Research Center for Obstetrics and Gynecology Diseases of Fujian Province, Laboratory of Research and Diagnosis of Gynecological Diseases of Xiamen City, Department of Obstetrics and Gynecology, the 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