{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:17:17Z","timestamp":1791001037999,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interleukin\u201041 (IL\u201041) is a newly discovered cytokine, named Cometin, Subfatin, meteorin\u2010like transcription (Metrnl), and so forth. It is widely expressed in animals and can exert its biological roles through autocrine and paracrine forms. It has functions such as anti\u2010inflammatory, improving body metabolism, regulating immunity, regulating fat metabolism and participates in the process of autoimmune disease or inflammatory injury. It plays an important role in psoriasis, diabetes, Crohn's disease (CD), osteoarthritis, Kawasaki disease (KD), Graves' disease, autoimmune hepatitis, infertility, obesity, sepsis, cardiovascular diseases and respiratory diseases. This paper reviews the biological functions of IL\u201041, the relationship between IL\u201041 and diseases, the effects of IL\u201041 in the cytokine network and the possible signalling pathways. In order to explore the same target or the same drug for the treatment of different diseases from the perspective of homotherapy for heteropathy, cytokine strategies based on IL\u201041 have been put forward for the precise treatment of immune diseases and inflammatory diseases. It is worth noting that IL\u201041 related preparations for lung protection and smoking cessation are interesting research fields.<\/jats:p>","DOI":"10.1111\/imm.13791","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T04:49:43Z","timestamp":1712724583000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Homotherapy for heteropathy: Interleukin\u201041 and its biological functions"],"prefix":"10.1111","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2149-1078","authenticated-orcid":false,"given":"Runfeng","family":"Shi","sequence":"first","affiliation":[{"name":"The First Clinical Medical College Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixin","family":"He","sequence":"additional","affiliation":[{"name":"School of Public Health Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine and Laboratory Medicine Zhujiang Hospital of Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Xia","sequence":"additional","affiliation":[{"name":"Southern Medical University Library  Guangzhou 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