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Despite significant advancements in the field of radioprotection, no drugs with high efficacy and low toxicity have yet been approved by the Food and Drug Administration. FG\u20104592, as a proline hydroxylase inhibitor, may play an important role in radioprotection of the haematopoietic system. Mice were peritoneal injected with FG\u20104592 or normal saline. After irradiation, the survival time, body weight, peripheral blood cell and bone marrow cell (BMC) count, cell apoptosis, pathology were analysed and RNA\u2010sequence technique (RNA\u2010Seq) was conducted to explore the mechanism of FG\u20104592 in the haematopoietic system. Our results indicated that FG\u20104592 improved the survival rate and weight of irradiated mice and protected the spleen, thymus and bone marrow from IR\u2010induced injury. The number of BMCs was increased and protected against IR\u2010induced apoptosis. FG\u20104592 also promoted the recovery of the blood system and erythroid differentiation. The results of RNA\u2010Seq and Western blot showed that the NF\u2010\u03baB signalling pathway and hypoxia\u2010inducible factor\u20101 (HIF\u20101) signalling pathway were upregulated by FG\u20104592. Meanwhile, RT\u2010PCR results showed that FG\u20104592 could promote inflammatory response significantly. FG\u20104592 exhibited radioprotective effects in the haematopoietic system by promoting inflammatory response and targeting the NF\u2010\u03baB, HIF signalling pathway.<\/jats:p>","DOI":"10.1111\/imm.13797","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T05:54:29Z","timestamp":1714456469000},"page":"614-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["FG\u20104592 protected haematopoietic system from ionising radiation in mice"],"prefix":"10.1111","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2676-049X","authenticated-orcid":false,"given":"Yuedong","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health and Management Wenzhou Medical University  Wenzhou China"},{"name":"Department of Radiation Medicine Faculty of Naval Medicine, Naval Medical University  Shanghai 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