{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:45:36Z","timestamp":1787161536447,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102092"],"award-info":[{"award-number":["32102092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Inflammatory bowel disease (IBD) and food allergy (FA) increase in tandem, but the potential impact of IBD on FA remains unclear. We sought to determine the role of IBD on FA. We first assessed the changes of FA\u2010related risk factors in dextran sulphate sodium salt (DSS) induced colitis mice model. Then, we evaluated the role of IBD on FA in mice. FA responses were determined using a clinical allergy score, body temperature change, serum antibody levels, cytokines level and mouse mast cell protease 1 (MMCP\u20101) concentration. Accumulation of regulatory T cells was tested using flow cytometry. Intestinal changes were identified by histology, immunohistochemistry, gene expression and gut microbial community structure. In DSS\u2010induced colitis mice model, we found the intestinal damage, colonic neutrophil infiltration, and downregulation of splenic Th2 cytokines and Tregs in mesenteric lymph nodes (MLN). Moreover, we also found that IBD can alleviate the FA symptoms and lead to the significant downregulation of Th2 cytokines, serum IgE and MMCP\u20101. However, IBD exacerbates intestinal injury and promotes the gene expression levels of IL\u201033 and IL\u20105 in the small intestine, damages the intestinal tissue structure and aggravates intestinal dysbiosis in FA. IBD functions as a double\u2010edged sword in FA. From the perspective of clinical symptoms and humoral immune responses, IBD can reduce FA response by downregulating Th2 cytokines. But from the perspective of the intestinal immune system, IBD potentially disrupts intestinal tolerance to food antigens by damaging intestinal tissue structure and causing intestinal dysbiosis.<\/jats:p>","DOI":"10.1111\/imm.13833","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T04:19:27Z","timestamp":1721017167000},"page":"394-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>IBD<\/scp>\n                    functions as a double\u2010edged sword for food allergy in\n                    <scp>BALB<\/scp>\n                    \/c mice model"],"prefix":"10.1111","volume":"173","author":[{"given":"Bihua","family":"Chen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Nanchang University  Nanchang China"},{"name":"College of Food Science and Technology, Nanchang University  Nanchang China"},{"name":"Jiangxi Province Key Laboratory of Food Allergy, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhong","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Nanchang University  Nanchang China"},{"name":"College of Food Science and Technology, Nanchang University  Nanchang China"},{"name":"Jiangxi Province Key Laboratory of Food Allergy, Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Nanchang University  Nanchang China"},{"name":"College of Food Science and Technology, Nanchang University  Nanchang China"},{"name":"Jiangxi Province Key Laboratory of Food Allergy, Nanchang University  Nanchang 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