{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:00:11Z","timestamp":1792555211889,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T00:00:00Z","timestamp":1726617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","award":["K7013\u2010B3414G"],"award-info":[{"award-number":["K7013\u2010B3414G"]}],"id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\u20101126"],"award-info":[{"award-number":["PI20\u20101126"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Migraine (MI) is the most common neurological disease, affecting with 20% of the world population. A subset of 25% of MI patients showcase concurrent vestibular symptoms, which may classify as vestibular migraine (VM). Meniere's disease (MD) is a complex inner ear disorder defined by episodes of vertigo associated with tinnitus and sensorineural hearing loss with a significant autoimmune\/autoinflammatory contribution, which symptoms overlap with VM. Blood samples from 18 patients with MI (5), VM (5) and MD (8) and 6 controls were collected and compared in a case\u2013control study. Droplet\u2010isolated nuclei from mononuclear cells used to generate scRNAseq and scATACseq data sets from MI, VM and MD. MI and VM have no differences in their immune transcriptome; therefore, they were considered as a single cluster for further analyses. Natural Killer (NK) cells transcriptomic data support a polarisation triggered by Type 1 innate immune cells via the release of interleukin (IL)\u201012, IL\u201015 and IL\u201018. According to the monocyte scRNAseq data, there were two MD clusters, one inactive and one driven by monocytes. The unique pathways of the MI\u2009+\u2009VM cluster were cellular responses to metal ions, whereas MD monocyte\u2010driven cluster pathways showed responses to biotic stimuli. MI and MD have different immune responses. These findings support that MI and VM have a Type 1 immune lymphoid cell response, and that there are two clusters of MD patients, one inactive and one Monocyte\u2010driven.<\/jats:p>","DOI":"10.1111\/imm.13863","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T23:30:18Z","timestamp":1726702218000},"page":"768-779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Multiomic\u2010based immune response profiling in migraine, vestibular migraine and Meniere's disease"],"prefix":"10.1111","volume":"173","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1699-3617","authenticated-orcid":false,"given":"Pablo","family":"Cruz\u2010Granados","sequence":"first","affiliation":[{"name":"Meniere Disease Neuroscience Research Program, Faculty of Medicine and Health, School of Medical Sciences, The Kolling Institute University of Sydney  Sydney New South Wales 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Instituto de Investigaci\u00f3n Biosanitaria, ibs.GRANADA Universidad de Granada  Granada Spain"},{"name":"Sensorineural Pathology Programme, Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Raras, CIBERER  Madrid Spain"},{"name":"Department of Otolaryngology Hospital Universitario San Cecilio, Instituto de Investigaci\u00f3n Biosanitaria, ibs.GRANADA  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9749-8607","authenticated-orcid":false,"given":"Juan Carlos","family":"Amor\u2010Dorado","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital Can Misses Ibiza  Ibiza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Dominguez\u2010Duran","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Hospital Infanta Luisa  Sevilla 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