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The endocytic route of dendritic cells (DCs) is highly specialised for cross\u2010presentation to initiate cytotoxic immune responses against numerous intracellular pathogens and tumours. In this study, we identify the endosomal protein sorting nexin (SNX) 17 as a key regulator of antigen internalisation and cross\u2010presentation by DCs. SNX17 expression in DCs guarantees optimal cross\u2010presentation of soluble, particulate, and <jats:italic>Toxoplasma gondii<\/jats:italic>\u2010associated antigens. The silencing of SNX17 expression in DCs significantly affected the internalisation of exogenous antigens by fluid\u2010phase endocytosis, phagocytosis, and more strikingly, <jats:italic>T<\/jats:italic>. <jats:italic>gondii<\/jats:italic> invasion. We show that SNX17 controls proper integrin recycling, actin cytoskeleton organisation, and phagosomal maturation. 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