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Computationally derived peptides were mapped and subjected to in silico docking, revealing promising targets for CD8+ cytotoxic and CD4+ helper T cells. Key factors analysed include solvent accessible surface area (SASA), Debye\u2010Waller factor (B\u2010factor), and polar bond interactions. Post\u2010docking, removal of <jats:italic>N<\/jats:italic>\u2010acetylglucosamine (NAG) increased peptide stability and reduced B\u2010factors, while SO4 presence had minimal impact. SASA values increased by up to 237.5% with MHC Class I, and RNA docking with MHC Class II displayed mixed SASA changes. Polar bond interactions also increased post\u2010docking, indicating the strong potential of identified CHPV epitopes.<\/jats:p>","DOI":"10.1111\/imm.13907","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T03:45:07Z","timestamp":1738727107000},"page":"52-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["X\u2010Ray Crystallography Based Epitope Mapping of Glycoproteins and <scp>RNA<\/scp> in Chandipura Vesiculovirus for Vaccine Design"],"prefix":"10.1111","volume":"175","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7279-3874","authenticated-orcid":false,"given":"Aron Rodrick","family":"Lakra","sequence":"first","affiliation":[{"name":"Independent 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