{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T04:01:56Z","timestamp":1749096116750,"version":"3.41.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Invariant natural killer T (iNKT) cells in peripheral tissues are from different waves ranged from foetal, neonatal to adult ages. However, it is unclear how iNKT cells from different ages maintain in the periphery and what are their functionality. We found that in adult mice, neonate tracked\u2010iNKT (NT\u2010iNKT) cells are present in spleen, bone marrow, liver and lung, with a predominantly accumulation in the kidney. The NT\u2010iNKT cells in the kidney are almost iNKT1 cells and express tissue\u2010resident marker CD69. These cells also exhibit higher level of CD122 and possess a stronger proliferative capacity compared to adult tracked\u2010iNKT (AT\u2010iNKT) cells. Furthermore, we found that NT\u2010iNKT cells potentially secrete more IFN\u2010\u03b3 than AT\u2010iNKT cells in\u00a0vitro and in\u00a0vivo (a\u2010GalCer immunisation). Overall, our study sheds light on the peripheral behaviour and functionality of NT\u2010 and AT\u2010iNKT cells, highlighting the potential role of NT\u2010iNKT cells in the kidney during immune response.<\/jats:p>","DOI":"10.1111\/imm.13909","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T08:49:53Z","timestamp":1739782193000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lineage Tracking Dissects the Fate of Neonatal <scp>iNKT<\/scp> Cells Later in Life"],"prefix":"10.1111","volume":"175","author":[{"given":"Jun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences Xi'an Jiaotong University  Xi'an China"},{"name":"Institute of Infection and Immunity, Translational Medicine Institute Xi'an Jiaotong University Health Science Center  Xi'an 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