{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:29:33Z","timestamp":1790342973640,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Leprosy, a chronic infectious disease caused by <jats:styled-content style=\"fixed-case\"><jats:italic>Mycobacterium leprae<\/jats:italic><\/jats:styled-content>, manifests in a spectrum of clinical forms and severity. This study investigated the percentage of CD8<jats:sup>+<\/jats:sup> T cells and their subpopulations (CD8<jats:sup>bright<\/jats:sup> and CD8<jats:sup>dim<\/jats:sup> T cells) in leprosy patients stratified by clinical forms, bacterial load, and age. No significant differences were observed in the overall percentage of CD8<jats:sup>+<\/jats:sup> T cells among healthy controls and leprosy patients. However, an increased percentage of CD8<jats:sup>dim<\/jats:sup> T cells and a decreased percentage of CD8<jats:sup>bright<\/jats:sup> T cells were associated with severe multibacillary and lepromatous forms of leprosy, independent of bacillary load. Further, these cellular profiles correlated more strongly with disease severity than with age, in spite of elderly multibacillary patients exhibiting significant reductions in CD8<jats:sup>bright<\/jats:sup> T cells and increases in CD8<jats:sup>dim<\/jats:sup> T cells compared to young or middle\u2010aged paucibacillary patients, but not compared to young and middle\u2010aged multibacillary patients. These findings suggest that CD8<jats:sup>bright<\/jats:sup> and CD8<jats:sup>dim<\/jats:sup> T cell profiles are critical indicators of disease progression and severity in leprosy, highlighting their potential as biomarkers for clinical evaluation.<\/jats:p>","DOI":"10.1111\/imm.13937","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:25:40Z","timestamp":1746498340000},"page":"444-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased <scp>CD8<sup>dim<\/sup><\/scp> and Decreased <scp>CD8<sup>bright<\/sup><\/scp> T Cells as Immunological Signature for Multibacilary Leprosy Patients"],"prefix":"10.1111","volume":"175","author":[{"given":"Yuri Scheidegger","family":"de Castro","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Biologia Do Reconhecer, Centro de Bioci\u00eancias e Biotecnologia, Universidade Estadual Do Norte Fluminense Darcy Ribeiro  Campos dos 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