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This review elucidates the intricate and synergistic relationship between chronic inflammation and cancer, further amplified by the compounding effects of climate change and contemporary sociopolitical polarisation. We examine how biological, environmental and psychosocial factors converge to worsen chronic inflammation and increase cancer risk. Addressing this \u201cperfect storm\u201d of converging health threats necessitates a holistic and integrated approach that considers biological vulnerabilities, environmental degradation, the socioeconomic burden of health inequities, and the profound societal impacts of political polarisation to effectively mitigate this escalating global health crisis and promote health equity.<\/jats:p>","DOI":"10.1111\/imm.70000","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T01:30:02Z","timestamp":1749605402000},"page":"304-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Inflammation Perfect Storm: Cancer, Climate and Polarisation"],"prefix":"10.1111","volume":"176","author":[{"given":"Claudio Vieira","family":"da Silva","sequence":"first","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia  Uberl\u00e2ndia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100675\u20100"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00071"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.142"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102010\u201007\u2010273417"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2013"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.140145"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.2.503"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.07.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/138620712799218608"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01322"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028662"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(19)30488\u20107"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05485"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753\u20104887.2007.tb00335.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000148"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/jir.s485159"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag2590"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/149185"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326\u20106066.CIR\u201022\u20100857"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20100136"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2024.104311"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10092116"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123752"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(00)04046\u20100"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1256"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/35025220"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3779\/CJLC.V12I11.1048"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0438053100"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2303"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(07)70139\u20109"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1279"},{"key":"e_1_2_7_37_1","volume-title":"Encyclopedia of Cancer","author":"Ognjanovic S.","year":"2009"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02\u20100752rev"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309356978"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2007.01.018"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00079.2004"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555\u2010022\u201010058\u20100"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v4.i3.62"},{"key":"e_1_2_7_44_1","unstructured":"Original [26] Hussain F Sultana M et\u00a0al. 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