{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:06:29Z","timestamp":1787843189980,"version":"build-2784847793"},"reference-count":81,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010318","name":"University of Manitoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tissue\u2010resident memory T (T\n                    <jats:sub>RM<\/jats:sub>\n                    ) cells are a specialised subset of immune cells that remain within tissues, playing a vital role in localised immune defence and long\u2010term immunity. Unlike circulating memory T cells, T\n                    <jats:sub>RM<\/jats:sub>\n                    cells do not recirculate to provide rapid and effective responses against previously encountered pathogens at the tissue level. The formation of T\n                    <jats:sub>RM<\/jats:sub>\n                    cells is driven by tissue\u2010specific cues, guiding their differentiation and retention within organs such as the skin, lungs and gut. They are characterised by the expression of unique markers, including CD69 and CD103, which facilitate their retention and longevity in tissues. T\n                    <jats:sub>RM<\/jats:sub>\n                    cells are essential for immune surveillance, effectively detecting and responding to different infections and contributing to tumour suppression. However, T\n                    <jats:sub>RM<\/jats:sub>\n                    cells are also implicated in chronic inflammatory and autoimmune diseases, where persistent activation by resident and autoantigens can lead to tissue damage. This pathogenic role is evident in chronic inflammatory conditions such as psoriasis, vitiligo and inflammatory bowel disease (IBD), where T\n                    <jats:sub>RM<\/jats:sub>\n                    cells may drive persistent localised inflammation and contribute to disease progression and severity. Emerging therapeutic strategies seek to modulate T\n                    <jats:sub>RM<\/jats:sub>\n                    cells to balance their protective and pathogenic roles in these inflammatory diseases. Approaches such as checkpoint inhibitors, cytokine modulation and cell\u2010depletion therapies aim to enhance T\n                    <jats:sub>RM<\/jats:sub>\n                    cells' beneficial immune functions while minimising their role in autoimmunity. A deeper understanding of T\n                    <jats:sub>RM<\/jats:sub>\n                    cell development, maintenance and functional diversity is critical for advancing treatments for infectious diseases, chronic inflammation, autoimmune conditions and cancer.\n                  <\/jats:p>","DOI":"10.1111\/imm.70024","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T04:24:31Z","timestamp":1754281471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tissue Resident Memory Cells: Friend or Foe?"],"prefix":"10.1111","author":[{"given":"Chidimma F.","family":"Chude","sequence":"first","affiliation":[{"name":"Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jude E.","family":"Uzonna","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Pathology, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0220-0076","authenticated-orcid":false,"given":"Janilyn","family":"Arsenio","sequence":"additional","affiliation":[{"name":"Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba  Winnipeg Manitoba Canada"},{"name":"Manitoba Centre for Proteomics and Systems Biology  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1093\/oxfimm\/iqae006","article-title":"The Emerging Role of Effector Functions Exerted by Tissue\u2010Resident Memory T Cells","volume":"5","author":"Norifumi I.","year":"2024","journal-title":"Oxford Open Immunology"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102249.1999.00920.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010021\u201000918\u20107"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo5871"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010024\u201011945\u2010z"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1375528"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210417"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aas9673"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010021\u201000590\u20103"},{"issue":"2","key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210495","article-title":"Comparative Analysis Reveals a Role for TGF\u2010\u03b2 in Shaping the Residency\u2010Related Transcriptional Signature in Tissue\u2010Resident Memory CD8 T Cells","volume":"14","author":"Nath A. 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