{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:33:46Z","timestamp":1767857626894,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006692","name":"Universit\u00e0 degli Studi di Torino","doi-asserted-by":"publisher","award":["RIBD_RILO_22_01"],"award-info":[{"award-number":["RIBD_RILO_22_01"]}],"id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006692","name":"Universit\u00e0 degli Studi di Torino","doi-asserted-by":"publisher","award":["CAVG_RILO_23_01"],"award-info":[{"award-number":["CAVG_RILO_23_01"]}],"id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Genetic factors, including single\u2010nucleotide variants (SNVs), may modulate disease course and therapeutic efficacy in patients with inflammatory bowel disease (IBD). We investigated the association between four SNVs in cytokine genes and clinical phenotype as well as the response to molecular\u2010targeted drugs in patients with IBD. A total of 197 IBD patients (142 Crohn's disease [CD], 55 ulcerative colitis [UC]) undergoing targeted treatment were enrolled. The SNVs analysed were:\n                    <jats:italic>TNFA<\/jats:italic>\n                    rs1800629 (\u2212308 G&gt;A),\n                    <jats:italic>TGFB<\/jats:italic>\n                    rs1800471 (\u2212codon 10 C&gt;T),\n                    <jats:italic>IL6<\/jats:italic>\n                    rs1800795 (\u2212174 G&gt;C), and\n                    <jats:italic>IL10<\/jats:italic>\n                    rs1800896 (\u22121082 G&gt;A). Biochemical response at 12\u2009months (T12) was defined as C\u2010reactive protein &lt;\u20095.0\u2009mg\/L and faecal calprotectin &lt;\u2009250\u2009\u03bcg\/g at T12, in the absence of ongoing corticosteroid therapy. Among the SNVs analysed, the\n                    <jats:italic>IL6<\/jats:italic>\n                    rs1800795 C allele was significantly associated with a younger age at diagnosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.049), while the\n                    <jats:italic>TNFA<\/jats:italic>\n                    rs1800629 A allele was more frequently observed in patients with CD than in UC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036). Regarding treatment response, 134 patients completed 12\u2009months of molecular\u2010targeted therapy and were included in the per\u2010protocol analysis; 41.0% achieved biochemical remission at T12. The\n                    <jats:italic>IL10<\/jats:italic>\n                    rs1800896 variant allele was significantly associated with remission (OR\u2009=\u20092.15, 95% CI: 1.03\u20134.44;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.041). This association remained significant in multivariate analysis (aOR\u2009=\u20094.15, 95% CI: 1.49\u201311.56;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007), independently of clinical and treatment\u2010related variables. In conclusion, genotyping of cytokine\u2010related SNVs may help identify patients with a more aggressive disease phenotype and guide personalised treatment strategies in patients with IBD.\n                  <\/jats:p>","DOI":"10.1111\/imm.70058","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T04:32:09Z","timestamp":1761798729000},"page":"432-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>\n                      <i>IL10<\/i>\n                    <\/scp>\n                    rs1800896 Genetic Variant Predicts Biochemical Remission in Inflammatory Bowel Disease Patients Undergoing Biologic Therapy"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6911-7327","authenticated-orcid":false,"given":"Michela Helga","family":"Falzone","sequence":"first","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-3087","authenticated-orcid":false,"given":"Davide Giuseppe","family":"Ribaldone","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin Italy"},{"name":"Division of Gastroenterology Citt\u00e0 della Salute e della Scienza \u2013 Molinette Hospital  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Buglione","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Cottone","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Vernero","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Citt\u00e0 della Salute e della Scienza \u2013 Molinette Hospital  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demis","family":"Pitoni","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Armandi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin Italy"},{"name":"Division of Gastroenterology Citt\u00e0 della Salute e della Scienza \u2013 Molinette Hospital  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-2994","authenticated-orcid":false,"given":"Francesca","family":"Saba","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Dileo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Santovito","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Systems Biology University of Turin  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Paolo","family":"Caviglia","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Turin  Turin 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