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Although LSP1 has been extensively studied in neutrophils and macrophages, its role in dendritic cells and tumour surveillance remains poorly understood. Here, we demonstrate that LSP1 deficiency in mice leads to increased growth of B16\u2010OVA melanoma, accompanied by reduced survival. Flow cytometry and histological analysis revealed lower total leukocyte content in the tumour microenvironment (TME) in LSP1 knockout (KO) mice compared to wild\u2010type (WT) mice, and a significant reduction in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and CD103\n                    <jats:sup>+<\/jats:sup>\n                    dendritic cells (DCs), as well as in additional immune cell populations, in tumour\u2010draining lymph nodes of LSP1 KO mice. In\u00a0vivo, DCs from LSP1 KO mice exhibited impaired antigen uptake and transportation to the tumour\u2010draining lymph node and a reduced in\u00a0vitro capacity to activate na\u00efve CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. These defects correlated with diminished in\u00a0vitro and in\u00a0vivo CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell priming and activation in LSP1\u2010deficient mice. Cytokine profiling of tumour homogenates from LSP1 KO mice revealed a complex inflammatory milieu, with elevated levels of both pro\u2010 and anti\u2010tumoural cytokines, including IL\u20101\u03b2, TNF\u2010\u03b1, IL\u201010, IL\u201017A, IFN\u03b2 IL\u201023, IL\u201027 and GM\u2010CSF. Our findings suggest that LSP1 plays a critical, cell\u2010intrinsic role in both DC and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell function, although we cannot exclude the possible role of other leukocyte populations. Its absence promotes tumour progression by disrupting key immune responses in the TME.\n                  <\/jats:p>","DOI":"10.1111\/imm.70064","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:49:18Z","timestamp":1763020158000},"page":"575-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Leukocyte Specific Protein 1 Deficiency Impairs Anti\u2010Melanoma Immunity by Disrupting\n                    <scp>DC<\/scp>\n                    and\n                    <scp>CD8<\/scp>\n                    <sup>+<\/sup>\n                    T Cell Function in Mice"],"prefix":"10.1111","volume":"177","author":[{"given":"Mar\u00eda Mercedes","family":"Pascual","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"},{"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI) Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s Daniel","family":"Dho","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"},{"name":"Centro de Investigaciones en Bioqu\u00edmica Cl\u00ednica e Inmunolog\u00eda (CIBICI) Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel Paola","family":"Acland Strack","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Cl\u00ednica, Facultad de Ciencias Qu\u00edmicas Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"},{"name":"Centro de Investigaciones en Bioqu\u00edmica 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