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Inflammasomes\u2014particularly those involving genes such as NLRP1, AIM2 and MEFV\u2014play a key role in this process. High\u2010intensity interval training (HIIT) can counteract this inflammation; however, it remains unclear how HIIT modulates inflammasome gene expression in obesity. This study investigated whether HIIT can alter the expression of genes related to the inflammasomes NLRP1, AIM2 and MEFV in obese individuals. The results showed that, after 8\u2009weeks of HIIT, there was an increase in the expression of the genes AIM2, MEFV, CARD16 and CARD18. The increase in CARD16, known to inhibit caspase\u20101 dimerisation, reinforces the hypothesis related to decreased inflammation, evidenced by the absence of clear activation of the NLRP1 inflammasome and by lower serum IL\u20101\u03b2 concentrations in trained participants. Although CARD18 was also upregulated, its function remains ambiguous, and it may act as an inhibitor or modulator of inflammation. Therefore, we conclude that HIIT is a promising intervention for modulating inflammatory genes in individuals with obesity, with the potential to reduce systemic inflammation and its pathological effects.<\/jats:p>","DOI":"10.1111\/imm.70090","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:09:35Z","timestamp":1766362175000},"page":"109-117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of\n                    <scp>NLRP1<\/scp>\n                    ,\n                    <scp>AIM2<\/scp>\n                    and\n                    <scp>MEFV<\/scp>\n                    Inflammasomes in the High\u2010Intensity Interval Training of Individuals With Obesity"],"prefix":"10.1111","volume":"178","author":[{"given":"Ana Lu\u00edza Pereira Assun\u00e7\u00e3o","family":"Silveira","sequence":"first","affiliation":[{"name":"Post Graduation Program in Health Sciences, Santo 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