{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T03:12:38Z","timestamp":1776222758162,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study was a post hoc analysis of a Phase III trial (NCT04839016), which aims to investigate whether early response to vunakizumab can predict long\u2010term efficacy in plaque psoriasis patients. A total of 461 plaque psoriasis patients receiving vunakizumab treatment were included for analysis. Early response to vunakizumab was defined by patients achieving a psoriasis area and severity index (PASI) 50 at week (W) 2. Efficacy analysis included PASI 75\/90\/100 and static physician's global assessment (sPGA) 0\/1 response rates in both groups. Safety was analysed in both groups. At W2, 249 patients achieved an early response; 212 did not. At W12, higher proportions of patients in the early response group achieved PASI 75\/90\/100 and sPGA 0\/1 versus the without early response group (98.4% vs. 88.2%, 88.0% vs. 66.0%, 50.2% vs. 25.0%, 84.7% vs. 64.6%, respectively; all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). The early response group had higher proportions of patients who maintained PASI 75\/90\/100 and sPGA 0\/1 from W12 to W52 versus the without early response group (88.8% vs. 76.4%, 74.7% vs. 54.7%, 39.4% vs. 20.8%, 68.7% vs. 54.2%, respectively; all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Multivariate logistic regression analysis showed that early response to vunakizumab was independently associated with PASI 100 response at W52 (odds ratio\u2009=\u20091.772,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027). The incidence of adverse events was similar between groups. Patients with moderate\u2010to\u2010severe plaque psoriasis receiving vunakizumab show a favourable clinical response, regardless of achieving early response or not. Particularly, patients with early response at Week 2 are significantly more likely to achieve better long\u2010term treatment outcomes.\n                  <\/jats:p>","DOI":"10.1111\/imm.70099","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T06:29:50Z","timestamp":1767335390000},"page":"162-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Response to Vunakizumab at Week 2 Predicts Favourable Long\u2010Term Efficacy in Patients With Moderate\u2010To\u2010Severe Plaque Psoriasis: A Post Hoc Analysis of a Phase\n                    <scp>III<\/scp>\n                    , Randomised Controlled Trial"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4633-8368","authenticated-orcid":false,"given":"Xiaoying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaohua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Huashan Hospital, Fudan University  Shanghai China"},{"name":"Worldwide Medical Center, Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiya","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai Skin Disease Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suwei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai Skin Disease Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fujuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai Skin Disease Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shanghai Skin Disease Hospital, Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-9679","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine  Shanghai China"},{"name":"Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113388"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122991"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.m2024.0064"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.29536"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"issue":"4","key":"e_1_2_10_7_1","first-page":"278","article-title":"Diagnosis and Management of Psoriasis","volume":"63","author":"Kim W. 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