{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:21:01Z","timestamp":1791566461092,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371810"],"award-info":[{"award-number":["82371810"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572056"],"award-info":[{"award-number":["82572056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171788"],"award-info":[{"award-number":["82171788"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372320"],"award-info":[{"award-number":["82372320"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To investigate the role of PANoptosis activation in anti\u2010melanoma differentiation\u2010associated protein 5 (MDA5) antibody\u2010positive dermatomyositis (anti\u2010MDA5+ DM). Transcriptomic profiling of peripheral blood mononuclear cells (PBMCs) from 40 patients with anti\u2010MDA5+ DM and 10 healthy controls (HCs) was performed. The PANoptosis signature score was constructed using single sample gene set enrichment analysis based on the mean enrichment scores of the pyroptosis, apoptosis and necroptosis gene sets, and the clinical associations of the PANoptosis signature score in patients with anti\u2010MDA5+ DM were evaluated. PANoptosis markers were analysed via western blotting, and the regulatory mechanism of PANoptosis activation was studied in Jurkat cells in\u00a0vitro. Transcriptomic profiling demonstrated overactivation of the PANoptosis signalling pathway in patients with anti\u2010MDA5+ DM. The PANoptosis signature score was positively correlated with inflammatory markers, type 1 interferon (IFN) signature score, disease severity and poor prognosis in patients with anti\u2010MDA5+ DM. Z\u2010DNA binding protein 1 (\n                    <jats:italic>ZBP1<\/jats:italic>\n                    ) was identified as a key PANoptosis\u2010related gene in anti\u2010MDA5+ DM. PANoptosis markers, including P\u2010MLKL, GSDMD\u2010N, cleaved caspase\u20108, cleaved caspase\u20103 and cleaved caspase\u20107, were significantly upregulated in T cells from patients with anti\u2010MDA5+ DM. Functional assays demonstrated that IFN\u2010\u03b2 induced PANoptosis activation in T cells in\u00a0vitro, which was significantly attenuated following ZBP1 knockdown. PANoptosis overactivation was associated with disease severity and prognosis in anti\u2010MDA5+ DM. Our findings indicated that IFN\u2010\u03b2 triggered ZBP1\u2010mediated PANoptosis in T cells, highlighting PANoptosis as a novel potential therapeutic target for anti\u2010MDA5+ DM.\n                  <\/jats:p>","DOI":"10.1111\/imm.70101","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T14:41:42Z","timestamp":1767710502000},"page":"174-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interferon\u2010\u03b2 Triggers Z\u2010\n                    <scp>DNA<\/scp>\n                    Binding Protein 1\u2010Mediated\n                    <scp>PANoptosis<\/scp>\n                    in T Cells of Anti\u2010Melanoma Differentiation\u2010Associated Protein 5 Antibody\u2010Positive Dermatomyositis"],"prefix":"10.1111","volume":"178","author":[{"given":"Xinxin","family":"Zhang","sequence":"first","affiliation":[{"name":"China\u2010Japan Friendship School of Clinical Medicine Peking University  Beijing China"},{"name":"Department of Rheumatology, Key Myositis Laboratories China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Wu","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship School of Clinical Medicine Peking University  Beijing China"},{"name":"Department of Rheumatology, Key Myositis Laboratories China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-6114","authenticated-orcid":false,"given":"Chao","family":"Sun","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship School of Clinical Medicine Peking University  Beijing China"},{"name":"Department of Rheumatology, Key Myositis Laboratories China\u2010Japan Friendship Hospital  Beijing 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China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-5244","authenticated-orcid":false,"given":"Yiran","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Key Myositis Laboratories China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship School of Clinical Medicine Peking University  Beijing China"},{"name":"Department of Rheumatology, Key Myositis Laboratories China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Pan","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship School of Clinical Medicine Peking University  Beijing China"},{"name":"Department of Rheumatology, Key Myositis Laboratories China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Shu","sequence":"additional","affiliation":[{"name":"China\u2010Japan Friendship School of Clinical Medicine Peking University  Beijing China"},{"name":"Department of Rheumatology, Key Myositis Laboratories China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Key Myositis Laboratories China\u2010Japan Friendship Hospital  Beijing 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