{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T14:56:38Z","timestamp":1785336998397,"version":"3.55.0"},"reference-count":68,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["408527\/2024\u20102"],"award-info":[{"award-number":["408527\/2024\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ08695\u201025"],"award-info":[{"award-number":["APQ08695\u201025"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["RED\u201000202\u201022"],"award-info":[{"award-number":["RED\u201000202\u201022"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["29568\u20101"],"award-info":[{"award-number":["29568\u20101"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ\u201002281\u201018"],"award-info":[{"award-number":["APQ\u201002281\u201018"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ\u201002618\u201023"],"award-info":[{"award-number":["APQ\u201002618\u201023"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ\u201004650\u201023"],"award-info":[{"award-number":["APQ\u201004650\u201023"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ\u201004983\u201024"],"award-info":[{"award-number":["APQ\u201004983\u201024"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.507175\/2020\u201001"],"award-info":[{"award-number":["88881.507175\/2020\u201001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008992","name":"International Society for Neurochemistry","doi-asserted-by":"publisher","award":["29344 ISID\/ICB\/DMORF\/ZIKA VIRUS"],"award-info":[{"award-number":["29344 ISID\/ICB\/DMORF\/ZIKA VIRUS"]}],"id":[{"id":"10.13039\/501100008992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["6205283B\u2010BB28\u20104F9C\u2010AA65\u2010808FE4450542"],"award-info":[{"award-number":["6205283B\u2010BB28\u20104F9C\u2010AA65\u2010808FE4450542"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Zika virus (ZIKV) is an emerging arbovirus belonging to the\n                    <jats:italic>Flaviviridae<\/jats:italic>\n                    family and Orthoflavivirus genus, with a pronounced tropism for the central nervous system (CNS), where it induces neuroinflammation and neuronal death. ZIKV is known to exploit host cellular mechanisms, including the activation of survival pathways such as the PI3K\/AKT signalling cascade, to evade apoptosis and enhance its replication. However, the role of the PI3K\u03b3 isoform in ZIKV\u2010induced neuroinflammation has not been previously explored, and this study aimed to investigate PI3K\u03b3 in ZIKV pathogenesis. Primary neuronal cultures from PI3K\u03b3\u2010deficient mice (PI3K\u03b3\n                    <jats:sup>kd\/kd<\/jats:sup>\n                    ) and human neuroblastoma SH\u2010SY5Y cells treated with the PI3K\u03b3 inhibitor AS605240 were infected with ZIKV to assess the impact of PI3K\u03b3 signalling on viral replication and neuronal survival. Additionally, interferon \u03b1\/\u03b2 receptor knockout (A129) mice were treated with AS605240 either before or after ZIKV infection to evaluate the pathway's role in neuroinflammation. In\u00a0vitro, both genetic ablation and pharmacological inhibition of PI3K\u03b3 suppressed ZIKV replication (~3% and ~17%, respectively) and prevented neuronal death (~16%). In\u00a0vivo, mice treated with the PI3K\u03b3 inhibitor exhibited enhanced protection against ZIKV infection, characterised by reduced viral load (~12%) and diminished brain and optic nerve damage. This neuroprotective effect correlated with reduced TNF production (about ~67%) by microglia. Furthermore, inhibition of PI3K\u03b3 curtailed the recruitment and activation of CD8+ T cells and decreased the production of pro\u2010inflammatory mediators, including IFN\u2010\u03b3 and IL\u201017, in the brains of ZIKV\u2010infected mice. These findings suggest that PI3K\u03b3 activation facilitates ZIKV infection and exacerbates neuroinflammation. Pharmacological inhibition of the PI3K\u03b3 pathway may offer therapeutic benefits by limiting viral replication and alleviating neuroinflammatory responses during ZIKV infection.\n                  <\/jats:p>","DOI":"10.1111\/imm.70113","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:54:15Z","timestamp":1770458055000},"page":"318-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>PI3K\u03b3<\/scp>\n                    Pathway Contributes to Neuroinflammation and Neuronal Death Induced by Zika Virus Infection"],"prefix":"10.1111","volume":"178","author":[{"given":"Danielle Cunha","family":"Teixeira","sequence":"first","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4473-3340","authenticated-orcid":false,"given":"Gabriel","family":"Campolina\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynecology and Reproduction, Faculty of Medicine, Universit\u00e9 Laval  Quebec QC Canada"},{"name":"CHU de Quebec Research Center\u2010Universit\u00e9 Laval  Quebec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Martins","family":"Marim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Rocha da Silva","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Martins","family":"Queiroz\u2010Junior","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Augusto Carvalho","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-0836","authenticated-orcid":false,"given":"Fernanda de Lima","family":"Tana","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Pedro","family":"Souza\u2010Costa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordane Clarisse","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Gomes","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Amorim","family":"Beltrami","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5105-1199","authenticated-orcid":false,"given":"Felipe Emanuel Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drielle Viana","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evandro Gon\u00e7alves","family":"Dornelas","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovana Cougo","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe Ferraz","family":"Dias","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Universidade Do Estado de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4534-2779","authenticated-orcid":false,"given":"Pedro Pires Goulart","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Toledo","family":"Ribas","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola Mara","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9621-5422","authenticated-orcid":false,"given":"Antonio Lucio","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Biggs Institute University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-7924","authenticated-orcid":false,"given":"Aline Silva","family":"de Miranda","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology Institute of Biological Sciences, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele da Gl\u00f3ria","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Microbiology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0175-642X","authenticated-orcid":false,"given":"Vivian Vasconcelos","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Morphology Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais  Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00032\u201016"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035\u20109203(52)90042\u20104"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004\u2010282X20160035"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i657"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15010096"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2022.100427"},{"key":"e_1_2_11_8_1","volume-title":"Zika: Data and Analysis \u2013 ARBO Portal","author":"Pan American Health Organization (PAHO)","year":"2025"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2005722117"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)00644\u20109"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1602964"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2016.08.297"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560\u20107917.ES.2016.21.16.30205"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw203"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000349"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518781992"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.1703"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24353"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642627"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13050896"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2024.107060"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.13.8388\u20108399.2005"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.10.007"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611681104"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2009.07.004"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.8.4240"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.12.006"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430\u2010014\u20100334\u20105"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001663"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01016"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009425"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00350\u201017"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202100842"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.702048"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119633"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0810464"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133149"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115981"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201044667\u20100"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01183\u201020"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600651"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010022\u201000701\u20108"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep25226"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.02.016"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978\u20100\u201012\u2010396456\u20104.00002\u2010X"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.18.9207\u20109217.2002"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00245\u201009"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/v5123192"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.07.019"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.02.035"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004658"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201002\u2010135715"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw878"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1515\/nipt\u20102022\u20100014"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2012.665461"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2020.05.023"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24491"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010018\u20101283\u20106"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017\u2010011\u20108154\u2010x"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02146"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/02648725.2023.2204719"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010022\u201002460\u20108"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13020325"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2024.115114"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010019\u20100427\u2010y"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.2012214"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2021039948"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.4.2081"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.70113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.70113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.70113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:56:54Z","timestamp":1778252214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.70113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,7]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/imm.70113"],"URL":"https:\/\/doi.org\/10.1111\/imm.70113","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,7]]},"assertion":[{"value":"2025-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}