{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:06:04Z","timestamp":1789538764352,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020\u201001287"],"award-info":[{"award-number":["2020\u201001287"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001424","name":"American Liver Foundation","doi-asserted-by":"publisher","award":["ALFGBG\u201070150"],"award-info":[{"award-number":["ALFGBG\u201070150"]}],"id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001424","name":"American Liver Foundation","doi-asserted-by":"publisher","award":["ALFGBG\u2010966039"],"award-info":[{"award-number":["ALFGBG\u2010966039"]}],"id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["21\u20101598 Pj"],"award-info":[{"award-number":["21\u20101598 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016290","name":"Insamlingsstiftelsen Cancer- och Allergifonden","doi-asserted-by":"publisher","award":["2022\u201010671"],"award-info":[{"award-number":["2022\u201010671"]}],"id":[{"id":"10.13039\/100016290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The intracellular, tick\u2010borne bacterium\n                    <jats:italic>Neoehrlichia (N.) mikurensis<\/jats:italic>\n                    can cause neoehrlichiosis in patients with compromised B\u2010cell defences, while immunocompetent individuals are frequently healthy carriers of the infection. We hypothesised that\n                    <jats:italic>N. mikurensis<\/jats:italic>\n                    induces latent infections that reactivate when B\u2010cell immunity is compromised. We tested this hypothesis by determining the incidence of\n                    <jats:italic>N. mikurensis<\/jats:italic>\n                    reactivation in 97 patients with B\u2010cell lymphomas who were treated with anti\u2010CD20 antibody therapy (rituximab) and evaluating the presence of\n                    <jats:italic>N. mikurensis<\/jats:italic>\n                    \u2010specific T cells in latently infected individuals. Four patients (4%) reactivated\n                    <jats:italic>N. mikurensis<\/jats:italic>\n                    infection and four patients (4%) had asymptomatic infection before the initiation of B\u2010cell suppression. All eight patients who were infected with\n                    <jats:italic>N. mikurensis<\/jats:italic>\n                    had\n                    <jats:italic>N. mikurensis<\/jats:italic>\n                    \u2010specific, perforin\u2010expressing Th1 and CD8+ T\u2010cell populations with up\u2010regulation of CXCL10 and IFN\u2010\u03b3, in contrast to the noninfected lymphoma patients who lacked these T\u2010cell subsets. The infected lymphoma patients also had expanded \u03b3\u03b4 T\u2010cell populations. This study supports the notion of latent, reactivatable\n                    <jats:italic>N. mikurensis<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1111\/imm.70120","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T07:26:57Z","timestamp":1770362817000},"page":"307-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Latent\n                    <i>Neoehrlichia mikurensis<\/i>\n                    Infections May Be Reactivated in Patients With B\u2010Cell Lymphomas Treated With Rituximab"],"prefix":"10.1111","volume":"178","author":[{"given":"Linda","family":"Wass","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Infectious Diseases, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Lewerin","sequence":"additional","affiliation":[{"name":"Department of Hematology and Coagulation Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Internal Medicine and Clinical Nutrition, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ja\u00e9n\u2010Luchoro","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Infectious Diseases, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1284-6911","authenticated-orcid":false,"given":"Christine","family":"Lingblom","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Infectious Diseases, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wenner\u00e5s","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Infectious Diseases, The Sahlgrenska Academy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1607.091907"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02423-09"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00588-10"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9071488"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.02.030"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu189"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1217"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1584017"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2022.2087732"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00741-14"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2108.150060"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2704.203366"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2021.1973347"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu441"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9102138"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-022-00737-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.65836-0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.10.2606-2611.1997"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2012.00336.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04339-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00694-9"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00130"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2019.0053"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149655"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2002.tb11038.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1841-1846.2001"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12922"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.3136"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0503-y"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830200534"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2012.43"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-03-417519"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18652"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10018-1"}],"container-title":["Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.70120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imm.70120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imm.70120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:56:42Z","timestamp":1778252202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imm.70120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/imm.70120"],"URL":"https:\/\/doi.org\/10.1111\/imm.70120","archive":["Portico"],"relation":{},"ISSN":["0019-2805","1365-2567"],"issn-type":[{"value":"0019-2805","type":"print"},{"value":"1365-2567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"2025-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}