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Here, we developed a C57BL\/6J\u2010\n                    <jats:italic>Ifng<\/jats:italic>\n                    \u20102A\u2010luciferase knock\u2010in mouse strain using CRISPR\/Cas9\u2010mediated homology\u2010directed repair, enabling real\u2010time bioluminescence imaging (BLI) of IFN\u03b3\u2010expressing cells by inserting a luciferase cassette under the endogenous\n                    <jats:italic>Ifng<\/jats:italic>\n                    promoter. The validation confirmed that this model is capable of directly detecting Poly(I:C) \u2010induced transient IFN\u03b3, enhancing intratumoral IFN\u03b3 signals upon anti\u2010PD\u20101\/CTLA\u20104 therapy, and dynamically tracking IFN\u03b3 expression during imiquimod\u2010induced psoriasis. This transgenic mouse model provides a powerful tool for non\u2010invasive, longitudinal tracking of IFN\u03b3\u2010expressing cells, offering novel insights into IFN\u03b3\u2010mediated immune regulation in inflammation and cancer. It holds promise for identifying IFN\u03b3\u2010related therapeutic targets and predicting responses to immunotherapies.\n                  <\/jats:p>","DOI":"10.1111\/imm.70127","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:02:44Z","timestamp":1772989364000},"page":"428-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Bioluminescence Reporter Mouse Strain for In\u00a0Vivo Imaging of\n                    <scp>IFN\u03b3<\/scp>\n                    Cell Localization and Function"],"prefix":"10.1111","volume":"178","author":[{"given":"Yang","family":"Guo","sequence":"first","affiliation":[{"name":"Shanghai Laboratory Animal Research Center  Shanghai 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