{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:59:47Z","timestamp":1780880387669,"version":"3.54.1"},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Leishmania<\/jats:italic>\n                    infections profoundly reshape host immunity, yet their impact on central T\u2010cell development remains underappreciated. The thymus, a key site for establishing a functional and self\u2010tolerant T\u2010cell repertoire, is highly sensitive to systemic inflammatory cues. Growing evidence indicates that parasitic diseases, including leishmaniasis, can perturb thymic structure and function through direct parasite presence or sustained inflammatory stress. Such disturbances may alter thymocyte maturation, leading to reduced T\u2010cell output and the release of cells with aberrant specificity. Beyond compromising protective immunity, these changes may create conditions favourable to immune dysregulation, including the emergence of autoimmune manifestations and a microenvironment permissive to malignant transformation. This narrative review synthesises current findings on how\n                    <jats:italic>Leishmania<\/jats:italic>\n                    interacts with immunological tissues and highlights the thymus as a potential and overlooked target whose dysfunction may bridge infection, autoimmunity and cancer.\n                  <\/jats:p>","DOI":"10.1111\/imm.70150","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:10:48Z","timestamp":1778857848000},"page":"377-386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thymus and\n                    <i>Leishmania<\/i>\n                    at the Crossroads: Autoimmunity and Cancer"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4504-7667","authenticated-orcid":false,"given":"Alef Batista Bezerra","family":"Barros","sequence":"first","affiliation":[{"name":"Laboratory of Cell Biology Institute of 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University of Alagoas  Macei\u00f3 Brazil"},{"name":"Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT\u2010NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8445-5189","authenticated-orcid":false,"given":"Luiz Henrique Agra","family":"Cavalcante\u2010Silva","sequence":"additional","affiliation":[{"name":"Medical Sciences and Nursing Complex Federal University of Alagoas  Arapiraca Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-0345","authenticated-orcid":false,"given":"Marvin Paulo","family":"Lins","sequence":"additional","affiliation":[{"name":"Brazilian National Institute of Science and Technology on Neuroimmunomodulation (INCT\u2010NIM), Oswaldo Cruz Institute, Oswaldo Cruz Foundation  Rio de Janeiro Brazil"},{"name":"Laboratory of Immunology, Department of Basic 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