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Through diverse molecular mechanisms, Tregs exert potent immunosuppressive effects that preserve self\u2010tolerance and mitigate aberrant immune activation. Dysregulation in Treg frequency or function is closely associated with the development of various immune\u2010mediated disorders. This has prompted extensive preclinical investigations and clinical trials evaluating the therapeutic potential of Tregs in conditions such as graft\u2010versus\u2010host disease, solid organ transplantation, and autoimmune diseases, which have yielded promising outcomes. This review provides a comprehensive overview of current preclinical and clinical applications of Treg\u2010based therapies, including adoptive Treg transfer, low\u2010dose IL\u20102, and CAR\u2010Treg therapy, and discusses their effectiveness in modulating immune responses across diverse pathological contexts.<\/jats:p>","DOI":"10.1111\/imm.70151","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:43:52Z","timestamp":1779270232000},"page":"1-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Current Status of Treg Therapy in Transplantation and Autoimmune Disease"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8354-7049","authenticated-orcid":false,"given":"Hongwen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology, The Seventh Affiliated Hospital Sun Yat\u2010sen University  Shenzhen 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