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The aim of this study was to evaluate antigen\u2010specific and polyclonal cellular immune responses in patients with MetS. Thirty\u2010two participants were divided into three groups: individuals with MetS in use of medication for metabolic conditions (MST), individuals with MetS without treatment (MS), and healthy donors (HD). Blood samples were collected, and peripheral blood mononuclear cells were obtained and stimulated in\u00a0vitro with peptide pools to evaluate antigen\u2010specific and polyclonal responses. Supernatants were collected for quantification of interleukin\u20102 (IL\u20102), interferon\u2010\u03b3 (IFN\u2010\u03b3), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and interleukin\u201010 (IL\u201010). Intragroup comparisons revealed that the MS group showed a more diverse cytokine production compared to the other groups after antigen\u2010specific stimulation, that could represent a more vigorous immune activation. The comparison of groups revealed that the MST group produced lower levels of IL\u20102 and IL\u201010 than HD and lower levels of TNF\u2010\u03b1 than the MS group after polyclonal stimulation. This attenuated response in the MST group may have multiple causes, such as the inhibitory effects of hyperglycemia on cytokines production and\/or the use of medication for metabolic conditions that may exhibit anti\u2010inflammatory effects. Therefore, the MS group demonstrated a broader cytokine production profile after antigen\u2010specific stimulation, whereas the MST group exhibited quantitatively lower cytokine production in response to polyclonal stimulation. 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