{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:30:43Z","timestamp":1786624243908,"version":"build-2736575974"},"reference-count":109,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFC2510600"],"award-info":[{"award-number":["2024YFC2510600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Autoimmune and autoinflammatory diseases are characterised by dysregulated immune activation and persistent inflammation, yet effective mechanism\u2010based therapeutic targets remain limited. Proline\u2010serine\u2013threonine phosphatase\u2010interacting protein 2 (PSTPIP2), a membrane\u2013cytoskeleton\u2010associated adaptor protein predominantly expressed in myeloid cells, has emerged as an important endogenous regulator of inflammatory responses. This review summarises the molecular structure, expression pattern and biological functions of PSTPIP2, with particular emphasis on its role in coordinating cytoskeletal remodelling, inflammatory signalling and immune\u2010cell behaviour. We further discuss the major mechanisms through which PSTPIP2 regulates disease progression, including suppression of IL\u20101\u03b2 maturation, inhibition of NF\u2010\u03baB and ERK signalling, modulation of macrophage polarisation and control of osteoclast\u2010associated bone remodelling. In addition, recent advances in understanding the involvement of PSTPIP2 in chronic multifocal osteomyelitis, rheumatoid arthritis, SAPHO syndrome and bullous pemphigoid are reviewed, together with evidence from\n                    <jats:italic>PSTPIP2<\/jats:italic>\n                    \u2010deficient models that has provided important mechanistic and translational insights. Finally, the potential value of PSTPIP2 as a biomarker and therapeutic target is highlighted. Overall, PSTPIP2 represents a critical immunoregulatory node linking cytoskeletal organisation to inflammatory control, and further investigation of its molecular functions may facilitate the development of precision therapies for autoimmune and autoinflammatory diseases.\n                  <\/jats:p>","DOI":"10.1111\/imm.70188","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:45:36Z","timestamp":1786621536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging Roles of\n                    <scp>PSTPIP2<\/scp>\n                    in Autoimmunity: From Mechanism to Therapeutic Implications"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1443-2483","authenticated-orcid":false,"given":"Erdong","family":"Zhang","sequence":"first","affiliation":[{"name":"Orthopaedic Research Institute of Hebei Province  Shijiazhuang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Institute of Hebei Province  Shijiazhuang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongle","family":"Wei","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Institute of Hebei Province  Shijiazhuang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Institute of Hebei Province  Shijiazhuang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9223-8782","authenticated-orcid":false,"given":"Liujie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Institute of Hebei Province  Shijiazhuang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jin","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Institute of Hebei Province  Shijiazhuang People's Republic of China"},{"name":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment Ministry of Education  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology The Third Hospital of Hebei Medical University  Shijiazhuang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingze","family":"Zhang","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Institute of Hebei Province  Shijiazhuang People's Republic of China"},{"name":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment Ministry of Education  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Orthopaedic Research Institute of Hebei Province  Shijiazhuang People's Republic of China"},{"name":"Department of Orthopedic Oncology Third Hospital of Hebei Medical University  Shijiazhuang People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-4025","authenticated-orcid":false,"given":"Zhiyong","family":"Hou","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment Ministry of Education  Shijiazhuang Hebei China"},{"name":"Key Laboratory of Biomechanics of Hebei Province  Shijiazhuang China"},{"name":"NHC Key Laboratory of Intelligent Orthopaedic Equipment  Shijiazhuang China"},{"name":"Key Laboratory of Precise Assessment, Diagnosis, and Treament of Soft Tissue Injury of Hebei Province  Shijiazhuang Hebei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02306","article-title":"Immune Checkpoints as Therapeutic Targets in Autoimmunity","volume":"9","author":"Paluch C.","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"e_1_2_15_3_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12016-013-8355-1","article-title":"Clinical Guidelines and Definitions of Autoinflammatory Diseases: Contrasts and Comparisons With Autoimmunity\u2014A Comprehensive Review","volume":"45","author":"Zen M.","year":"2013","journal-title":"Clinical Reviews in Allergy and Immunology"},{"issue":"4","key":"e_1_2_15_4_1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00281-015-0493-5","article-title":"New Monogenic Autoinflammatory Diseases\u2014A Clinical Overview","volume":"37","author":"Canna S. 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