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Recent advances support the emerging concept of a gut\u2013meningeal immune axis, wherein the gut microbiota may influence meningeal immunity, through the recruitment of gut\u2010educated immune cells and other microbiota\u2010dependent signals, although the mechanisms involved remain incompletely understood. Notably, the neonatal period represents a critical window of immune and microbial development, during which dysbiosis can disrupt microglia maturation, cytokine balance, and long\u2010term neuroimmune resilience. Here, we review the structural and immunological properties of the meninges, the mechanisms potentially linking the gut microbiota to meningeal immunity, and the role of this emerging axis in neuroinflammatory diseases. We further explore the developmental implications of early\u2010life microbial disturbances and discuss the therapeutic potential of microbiota\u2010targeted interventions to modulate meningeal immunity and mitigate CNS pathology.<\/jats:p>","DOI":"10.1111\/imm.70190","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:49:51Z","timestamp":1786582191000},"page":"554-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut\u2010Meningeal Immunity: A Missing Link in Neuroinflammatory Disorders"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3029-5060","authenticated-orcid":false,"given":"Nuno","family":"Ribeiro","sequence":"first","affiliation":[{"name":"ICBAS \u2010 School of Medicine and Biomedical Sciences Universidade do Porto  Porto Portugal"},{"name":"i3S \u2010 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, 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