{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:14:13Z","timestamp":1788401653225,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010481","name":"Etablissement Fran\u00e7ais du Sang","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010481","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Immunology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Plasmacytoid dendritic cells (PDCs) represent a crucial bridge between innate and adaptive immunity as they can recognise viruses and viral\u2010infected cells, secrete type I interferon and prime naive T\u2010cell responses. Like naive T cells, PDCs express CD62L, an essential molecule involved in the trans\u2010endothelial migration process, and are supposed to travel directly from blood to lymph nodes to prime naive T cells. We developed a therapeutic PDC line model (PDC*line) derived from a patient with blastic PDC neoplasm, and showing high antigen\u2010presentation capacities. PDC*line\u2010based vaccine was tested in clinical trials in melanoma and lung cancer. Efficient specific T lymphocyte priming was observed suggesting the efficient migration of injected PDC*line\u2010based vaccine to lymph nodes. Here, we investigated the mechanisms involved in this migration and its regulation. In humanised mice, our results demonstrated the efficient migration of the PDC\u2010based vaccine from blood to lymph nodes and its capacity to prime naive T cells. The expression of CD62L was evaluated following irradiation, which was mandatory in the vaccine manufacturing step and possibly important for its efficacy. CD62L was rapidly shed after irradiation of PDC*line cells and primary PDCs but not of NK\u2010T cells, demonstrating the cell specificity of the mechanism. Our results show that p38 MAP kinase, known to be activated in response to irradiation and ADAM17 metalloprotease are involved in the rapid CD62L shedding. This new pathway could participate to the regulation PDC transmigration through High Endothelial Venules and homing to secondary lymphoid organs in cellular stress conditions.<\/jats:p>","DOI":"10.1111\/imm.70194","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:34:49Z","timestamp":1788399289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Irradiation\u2010Induced\n                    <scp>CD62L<\/scp>\n                    Shedding in Human Plasmacytoid Dendritic Cells Depends on\n                    <scp>ADAM17<\/scp>\n                    and p38\n                    <scp>MAPK<\/scp>"],"prefix":"10.1111","author":[{"given":"Estelle","family":"Leplus","sequence":"first","affiliation":[{"name":"PDC*Line Pharma SAS  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamila","family":"Kacher","sequence":"additional","affiliation":[{"name":"PDC*Line Pharma SAS  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5097-1401","authenticated-orcid":false,"given":"Dalil","family":"Hannani","sequence":"additional","affiliation":[{"name":"PDC*Line Pharma SAS  Grenoble France"},{"name":"Universit\u00e9 Grenoble Alpes, CNRS, UMR 5525, VetAgro Sup, Grenoble INP, TIMC  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Vayssiere","sequence":"additional","affiliation":[{"name":"PDC*Line Pharma SAS  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Paul","family":"Molens","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Institute for Advanced Biosciences (IAB), Team Translational Immunology and Immunotherapy in Chronic Disease  Grenoble France"},{"name":"Recherche et D\u00e9veloppement, Etablissement Fran\u00e7ais du Sang Auvergne\u2010Rh\u00f4ne\u2010Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Laulanier","sequence":"additional","affiliation":[{"name":"PDC*Line Pharma SAS  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Georgess","sequence":"additional","affiliation":[{"name":"TransCure bioServices  Archamps France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-3801","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Josserand","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Institute for Advanced Biosciences (IAB), Optimal  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8857-9939","authenticated-orcid":false,"given":"Philippe","family":"Saas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Institute for Advanced Biosciences (IAB), Team Translational Immunology and Immunotherapy in Chronic Disease  Grenoble France"},{"name":"Recherche et D\u00e9veloppement, Etablissement Fran\u00e7ais du Sang Auvergne\u2010Rh\u00f4ne\u2010Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Planel","sequence":"additional","affiliation":[{"name":"PDC*Line Pharma SAS  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-9410","authenticated-orcid":false,"given":"Laurence","family":"Chaperot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Inserm U 1209, CNRS UMR 5309, Institute for Advanced Biosciences (IAB), Team Translational Immunology and Immunotherapy in Chronic Disease  Grenoble France"},{"name":"Recherche et D\u00e9veloppement, Etablissement Fran\u00e7ais du Sang Auvergne\u2010Rh\u00f4ne\u2010Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5005-4301","authenticated-orcid":false,"given":"Joel","family":"Plumas","sequence":"additional","affiliation":[{"name":"PDC*Line Pharma SAS  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1126\/science.aah4573","article-title":"Single\u2010Cell RNA\u2010Seq Reveals New Types of Human Blood Dendritic Cells, Monocytes, and Progenitors","volume":"356","author":"Villani A. 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M.","year":"2024","journal-title":"Annual Review of Immunology"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007111","article-title":"Plasmacytoid Dendritic Cells Capture and Cross\u2010Present Viral Antigens From Influenza\u2010Virus Exposed Cells","volume":"4","author":"Lui G.","year":"2009","journal-title":"PLoS One"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/ni.1602","article-title":"Direct Proteasome\u2010Independent Cross\u2010Presentation of Viral Antigen by Plasmacytoid Dendritic Cells on Major Histocompatibility Complex Class I","volume":"9","author":"Di Pucchio T.","year":"2008","journal-title":"Nature Immunology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/11360","article-title":"Plasmacytoid Monocytes Migrate to Inflamed Lymph Nodes and Produce Large Amounts of Type I Interferon","volume":"5","author":"Cella M.","year":"1999","journal-title":"Nature Medicine"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.20020437","article-title":"The Inducible CXCR3 Ligands Control Plasmacytoid Dendritic Cell Responsiveness to the Constitutive Chemokine Stromal Cell\u2013Derived Factor 1 (SDF\u20101)\/CXCL12","volume":"198","author":"Vanbervliet B.","year":"2003","journal-title":"Journal of Experimental Medicine"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fimmu.2013.00372","article-title":"Human Plasmacytoid Dendritic Cells: From Molecules to Intercellular Communication Network","volume":"4","author":"Mathan T. 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