{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:08:47Z","timestamp":1791410927130,"version":"4.3.3"},"reference-count":138,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,15]],"date-time":"2013-08-15T00:00:00Z","timestamp":1376524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The host response to viruses includes multiple cell types that have regulatory function. Most information focuses on\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    4\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells that express the transcription factor Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    (Tregs), which are the topic of this review. We explain how viruses through specific and non\u2010specific means can trigger the response of thymus\u2010derived natural Tregs as well as induce Tregs. The latter derive under appropriate stimulation conditions either from uncommitted precursors or from differentiated cells that convert to become Tregs. We describe instances where Tregs appear to limit the efficacy of antiviral protective immunity and other, perhaps more common, immune\u2010mediated inflammatory conditions, where the Tregs function to limit the extent of tissue damage that occurs during a virus infection. We discuss the controversial roles that Tregs may play in the pathogenesis of human immunodeficiency and hepatitis C virus infections. The issue of plasticity is discussed, as this may result in Tregs losing their protective function when present in inflammatory environments. Finally, we mention approaches used to manipulate Treg numbers and function and assess their current value and likely future success to manage the outcome of virus infection, especially those that are responsible for chronic tissue damage.\n                  <\/jats:p>","DOI":"10.1111\/imr.12085","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T01:59:52Z","timestamp":1376618392000},"page":"182-196","source":"Crossref","is-referenced-by-count":212,"title":["Role of regulatory T cells during virus infection"],"prefix":"10.1111","volume":"255","author":[{"given":"Tamara","family":"Veiga\u2010Parga","sequence":"first","affiliation":[{"name":"Department of Biomedical and Diagnostic Sciences College of Veterinary Medicine University of Tennessee Knoxville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharvan","family":"Sehrawat","sequence":"additional","affiliation":[{"name":"Institute of Life Sciences Nalco Square Bhubaneswar 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