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Beginning in the thymus and continuing into the periphery, these interactions, refined by accessory molecules, direct the expansion, differentiation, and function of T\u2010cell subsets. The cellular context of T\u2010cell engagement with antigen\u2010presenting cells, either in lymphoid or non\u2010lymphoid tissues, plays an important role in determining how these cells respond to antigen encounters.\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    8\n                    <jats:sup>+<\/jats:sup>\n                    T cells are essential for clearance of a lymphocytic choriomeningitis virus (\n                    <jats:styled-content style=\"fixed-case\">LCMV<\/jats:styled-content>\n                    ) infection, but the virus can present a number of unique challenges that antiviral T cells must overcome. Peripheral\n                    <jats:styled-content style=\"fixed-case\">LCMV<\/jats:styled-content>\n                    infection can lead to rapid cytolytic clearance or chronic viral persistence; central nervous system infection can result in T\u2010cell\u2010dependent fatal meningitis or an asymptomatic carrier state amenable to immunotherapeutic clearance. These diverse outcomes all depend on interactions that require\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    engagement of cognate peptide\u2010\n                    <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\n                    complexes. In this review, we explore the diversity in antiviral T\u2010cell behaviors resulting from\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    engagement, beginning with an overview of the immunological synapse and progressing to regulators of\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    signaling that shape the delicate balance between immunopathology and viral clearance.\n                  <\/jats:p>","DOI":"10.1111\/imr.12093","type":"journal-article","created":{"date-parts":[[2013,8,16]],"date-time":"2013-08-16T01:59:52Z","timestamp":1376618392000},"page":"110-124","source":"Crossref","is-referenced-by-count":24,"title":["The great balancing act: regulation and fate of antiviral T\u2010cell interactions"],"prefix":"10.1111","volume":"255","author":[{"given":"E. 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