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T\u2010cell therapy is one such area where recent trials using T cells genetically modified to express an antibody\u2010based chimeric antigen receptor (<jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content>) targeted against the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19 antigen have demonstrated impressive responses when adoptively transferred to patients with advanced chronic lymphocytic leukemia. The general concept of the <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content> T cell was devised some 20\u00a0years ago. In this relatively short period of time, the technology to redirect T\u2010cell function has moved at pace facilitating clinical translation; however, many questions remain with respect to developing the approach to improve <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content> T\u2010cell therapeutic activity and also to broaden the range of tumors that can be effectively targeted by this approach. This review highlights some of the underlying principles and compromises of <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content> T\u2010cell technology using the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>19\u2010targeted <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content> as a paradigm and discusses some of the issues that relate to targeting solid tumors with <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content> T cells.<\/jats:p>","DOI":"10.1111\/imr.12126","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T10:17:13Z","timestamp":1386929833000},"page":"91-106","source":"Crossref","is-referenced-by-count":105,"title":["<scp>CAR<\/scp> T cells: driving the road from the laboratory to the clinic"],"prefix":"10.1111","volume":"257","author":[{"given":"Eleanor J.","family":"Cheadle","sequence":"first","affiliation":[{"name":"Clinical and Experimental Immunotherapy Group Department 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