{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:23:16Z","timestamp":1787505796605,"version":"build-2736575974"},"reference-count":81,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T00:00:00Z","timestamp":1386892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunological Reviews"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Hematopoietic stem cells (\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    s) provide an attractive target for immunotherapy of cancer and leukemia by the introduction of genes encoding T\u2010cell receptors (\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    s) or chimeric antigen receptors (\n                    <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content>\n                    s) directed against tumor\u2010associated antigens.\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    s engraft for long\u2010term blood cell production and could provide a continuous source of targeted anti\u2010cancer effector cells to sustain remissions. T cells produced\n                    <jats:italic>de novo<\/jats:italic>\n                    from\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    s may continuously replenish anti\u2010tumor T cells that have become anergic or exhausted from\n                    <jats:italic>ex vivo<\/jats:italic>\n                    expansion or exposure to the intratumoral microenvironment. In addition, transgenic T cells produced\n                    <jats:italic>in vivo<\/jats:italic>\n                    undergo allelic exclusion, preventing co\u2010expression of an endogenous\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    that could mis\u2010pair with the introduced\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    chains and blunt activity or even cause off\u2010target reactivity.\n                    <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content>\n                    \u2010engineered\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    s may produce myeloid and natural killer cells in addition to T cells expressing the\n                    <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content>\n                    , providing broader anti\u2010tumor activity that arises quickly after transplant and does not solely require\n                    <jats:italic>de novo<\/jats:italic>\n                    thymopoiesis. Use of\n                    <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\n                    \u2010 or\n                    <jats:styled-content style=\"fixed-case\">CAR<\/jats:styled-content>\n                    \u2010engineered\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    s would likely require cytoreductive conditioning to achieve long\u2010term engraftment, and this approach may be used in clinical settings where autologous\n                    <jats:styled-content style=\"fixed-case\">HSC<\/jats:styled-content>\n                    transplant is being performed to add a graft\u2010versus\u2010tumor effect. Results of experimental and preclinical studies performed to date are reviewed.\n                  <\/jats:p>","DOI":"10.1111\/imr.12128","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T05:17:13Z","timestamp":1386911833000},"page":"237-249","source":"Crossref","is-referenced-by-count":78,"title":["Hematopoietic stem cells for cancer immunotherapy"],"prefix":"10.1111","volume":"257","author":[{"given":"Eric","family":"Gschweng","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics University of California, Los Angeles David Geffen School of Medicine Los Angeles CA USA"},{"name":"Eli and Edythe Broad Center for Regenerative Medicine &amp; Stem Cell Research University of California, Los Angeles David Geffen School of Medicine Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satiro","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Department 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