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Recent clinical trials have demonstrated that anti\u2010tumor adoptive T\u2010cell therapy, i.e. infusion of tumor\u2010specific T cells, can induce clinically relevant and sustained responses in patients with advanced cancer. The goal of adoptive cell therapy is to establish anti\u2010tumor immunologic memory, which can result in life\u2010long rejection of tumor cells in patients. To achieve this goal, during the process of <jats:italic>in vitro<\/jats:italic> expansion, T\u2010cell grafts used in adoptive T\u2010cell therapy must be appropriately educated and equipped with the capacity to accomplish multiple, essential tasks. Adoptively transferred T cells must be endowed, prior to infusion, with the ability to efficiently engraft, expand, persist, and traffic to tumor <jats:italic>in vivo<\/jats:italic>. 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