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Highly specialized antigen\u2010presenting cell (<jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>) subsets present in the gut play a dominant role in balancing these seemingly disparate functions. In this review, we discuss new findings associated with the function of gut <jats:styled-content style=\"fixed-case\">APC<\/jats:styled-content>s and particularly the contextual role of these cells in both establishing tolerance to orally acquired antigens in the steady state and regulating acute inflammation during infection.<\/jats:p>","DOI":"10.1111\/imr.12167","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T07:12:07Z","timestamp":1397027527000},"page":"75-87","source":"Crossref","is-referenced-by-count":28,"title":["Contextual functions of antigen\u2010presenting cells in the gastrointestinal tract"],"prefix":"10.1111","volume":"259","author":[{"given":"John R.","family":"Grainger","sequence":"first","affiliation":[{"name":"Program in Barrier Immunity and Repair, Mucosal Immunology Section Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Disease (NIAID) National Institutes of Health (NIH) Bethesda MD 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